78660-85-2

Basic information

• Product Name: 3-hydroxy-3-[2-oxo-2-(thiophen-2-yl)ethyl]-1,3-dihydro-2H-indol-2-one
• Synonyms: 3-hydroxy-3-[2-oxo-2-(thiophen-2-yl)ethyl]-1,3-dihydro-2H-indol-2-one
• CAS NO: 78660-85-2
• Molecular Formula: C14H11NO3S
• Molecular Weight: 273.30704
• Mol File: 78660-85-2.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-hydroxy-3-[2-oxo-2-(thiophen-2-yl)ethyl]-1,3-dihydro-2H-indol-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-3-[2-oxo-2-(thiophen-2-yl)ethyl]-1,3-dihydro-2H-indol-2-one(78660-85-2)
• EPA Substance Registry System: 3-hydroxy-3-[2-oxo-2-(thiophen-2-yl)ethyl]-1,3-dihydro-2H-indol-2-one(78660-85-2)

Safety Data

• Hazardous Substances Data: 78660-85-2(Hazardous Substances Data)

Upstream product

• 88-15-3 2-Acetylthiophene 
• 91-56-5 indole-2,3-dione 
• 69931-93-7 3-oxo-3-(thiophen-2-yl)propanoic acid 

Downstream Products

• 31792-47-9 2-(thiophen-2-yl)quinoline-4-carboxylic acid 

Relevant articles and documents

"on Water" Catalytic Aldol Reaction between Isatins and Acetophenones: Interfacial Hydrogen Bonding and Enamine Mechanism

"On water" catalytic aldol reaction catalyzed by polyetheramine (D230) has been developed for easy access to 3-substituted 3-hydroxyindolin-2-ones through the reaction between various substituted isatins and acetophenones/cyclic ketones in high yields under room temperature. Systematic mechanism investigation uncovers the secret for the on water catalytic aldol reaction: comparison of the heterogeneous and homogeneous reaction circumstances with yields of 95 and 20%, respectively, indicates the on-water reaction dominating; interfacial hydrogen bonding between isatin with H2O is tested based on the downfield shift of the C2 and C3's 13C NMR signals when water was added to the CDCl3 solution of isatin; Lewis base polyetheramine D230 catalyzes the aldol reaction via the enamine mechanism verified by in situ NMR and ESI-MS analysis.

Synthesis and antimicrobial activity of some novel 2-thienyl substituted heterocycles

A series of 2-thienyl substituted derivatives of thiazoles, oxazoles and spiro(indole-azole) were synthesized. The structures of the synthesized compounds were confirmed by IR, NMR and mass spectral data.

Molecular sieve mediated decarboxylative Mannich and aldol reactions of β-ketoacids

A molecular sieve mediated decarboxylative Mannich reaction of β-ketoacids with sulfonyl imines is reported; this protocol leads to an efficient preparation of synthetically useful β-amino ketones. An analogous molecular sieve promoted decarboxylative aldol reaction between β-ketoacids and isatins is also described, which affords bioactive 3-substituted-3-hydroxy-oxindoles in excellent yields.