31930-18-4

Basic information

• Product Name: 2-AMINO-4-NITROBENZAMIDE
• Synonyms: 2-Amino-4-nitrobenzamide95%;2-AMINO-4-NITROBENZAMIDE 95%;2-AMINO-4-NITROBENZAMIDE
• CAS NO: 31930-18-4
• Molecular Formula: C₇H₇N₃O₃
• Molecular Weight: 181.15
• Mol File: 31930-18-4.mol
• Article Data: 14

Chemical Properties

• Melting Point: 222-224 °C
• Boiling Point: 389.54 °C at 760 mmHg
• Flash Point: 189.388 °C
• Appearance: /
• Density: 1.482 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.676
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 14.79±0.50(Predicted)
• CAS DataBase Reference: 2-AMINO-4-NITROBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-4-NITROBENZAMIDE(31930-18-4)
• EPA Substance Registry System: 2-AMINO-4-NITROBENZAMIDE(31930-18-4)

Safety Data

• Hazardous Substances Data: 31930-18-4(Hazardous Substances Data)

Usage

General Description

2-AMINO-4-NITROBENZAMIDE is a chemical compound that consists of a benzene ring with an amino group and a nitro group attached to it. It has the molecular formula C7H6N4O3 and a molecular weight of 182.15 g/mol. 2-AMINO-4-NITROBENZAMIDE is commonly used in the synthesis of pharmaceuticals, dyes, and agrochemicals. It has also been studied for its potential as an anti-cancer agent due to its inhibitory effects on certain enzymes. Additionally, it is used as a reagent in organic chemistry reactions and as a building block for the preparation of various organic compounds.

InChI:InChI=1/C7H7N3O3/c8-6-3-4(10(12)13)1-2-5(6)7(9)11/h1-3H,8H2,(H2,9,11)

Upstream product

• 62242-95-9 2-amino-4-nitrobenzoyl chloride 
• 619-17-0 4-Nitroanthranilic acid 
• 13296-87-2 2,4-dinitrobenzamide 
• 3011-89-0 Novastat 
• 63480-10-4 4-nitroisatoic anhydride 

Downstream Products

• 87376-25-8 2-amino-4-nitro-benzonitrile 
• 20872-93-9 7-nitroquinazolin-4(3H)-one 
• 19815-17-9 4-chloro-7-nitroquinazoline 
• 344455-12-5 [2-(4-chloro-phenyl)-ethyl]-(7-nitro-quinazolin-4-yl)-amine 
• 6943-17-5 6-nitroquinazolone 
• 651733-09-4 2-(aminomethyl)-5-nitroaniline 
• 1223452-56-9 2,3-dihydro-7-nitro-2-phenyl-4(1H)-quinazolinone 
• 1319212-81-1 2-(4,6-dichloro-[1,3,5]triazin-2-ylamino)-4-nitrobenzamide 
• 1319212-82-2 2-{4,6-bis(isobutylamino)-[1,3,5]triazin-2-ylamino}-4-nitrobenzamide 
• 1319212-83-3 4-amino-2-{4,6-bis(isobutylamino)-[1,3,5]triazin-2-ylamino}benzamide 
• 26059-83-6 7-Nitro-2-phenyl-1,3-benzoxazin-2-one 

Relevant articles and documents

Discovery of 5-methyl-N-(2-arylquinazolin-7-yl)isoxazole-4-carboxamide analogues as highly selective FLT3 inhibitors

A series of 4-arylamido 5-methylisoxazole derivatives with quinazoline core was designed and synthesised based on conformational rigidification of a previous type II FMS inhibitor. Most of quinazoline analogues displayed activity against FLT3 and FLT3-ITD. Compound 7d, 5-methyl-N-(2-(3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl)quinazolin-7-yl)isoxazole-4-carboxamide, exhibited the most potent inhibitory activity against FLT3 (IC50= 106 nM) with excellent selectivity profiles over 36 other protein kinases including cKit and FMS kinase. Compound 7d was also active in FLT-ITD, with an IC50 value of 301 nM, and other FLT3 mutants showing potential as an AML therapeutics.

Synthesis and nematicidal activities of 1,2,3-benzotriazin-4-one containing 4,5-dihydrothiazole-2-thiol derivatives against Meloidogyne incognita

A series of novel 1,2,3-benzotriazin-4-one derivatives containing 4,5-dihydrothiazole-2-thiol were synthesized and characterized by 1H NMR, 13C NMR, 19F NMR and HRMS. The bioassay results showed that compounds 3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)-7-methoxybenzo[d][1–3]triazin-4(3H)-one, 3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)-6-nitrobenzo[d][1–3]triazin-4(3H)-one, 7-chloro-3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)benzo[d][1–3]triazin-4(3H)-one exhibited good control efficacy against the cucumber root-knot nematode disease caused by Meloidogyne incognita at the concentration of 10.0 mg L?1 in vivo. Compound 7-chloro-3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)benzo[d][1–3]triazin-4(3H)-one showed excellent nematicidal activity with inhibition 68.3% at a concentration of 1.0 mg L?1. It suggested that the structure of 1,2,3-benzotriazin-4-one containing 4,5-dihydro-thiazole-2-thiol could be optimized further.

Visible-light induced copper(i)-catalyzed oxidative cyclization of: O -aminobenzamides with methanol and ethanol via HAT

The use of the in situ generated ligand-copper superoxo complex absorbing light energy to activate the alpha C(sp3)-H of MeOH and EtOH via the hydrogen atom transfer (HAT) process for the synthesis of quinazolinones by oxidative cyclization of alcohols with o-aminobenzamide has been investigated. The synthetic utility of this protocol offers an efficient synthesis of a quinazolinone intermediate for erlotinb (anti-cancer agent) and 30 examples were reported.