32415-91-1

Basic information

• Product Name: 2-THIOPHENECARBONITRILE,5-FLUORO-
• Synonyms: 2-THIOPHENECARBONITRILE,5-FLUORO-;5-Cyano-2-fluorothiophene;2-Cyano-5-fluorothiophene;5-Fluorothiophen-2-carbonitrile
• CAS NO: 32415-91-1
• Molecular Formula: C₅H₂FNS
• Molecular Weight: 127.14
• Mol File: 32415-91-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 189.4±20.0 °C(Predicted)
• Appearance: /
• Density: 1.34±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 2-THIOPHENECARBONITRILE,5-FLUORO-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-THIOPHENECARBONITRILE,5-FLUORO-(32415-91-1)
• EPA Substance Registry System: 2-THIOPHENECARBONITRILE,5-FLUORO-(32415-91-1)

Safety Data

• Hazardous Substances Data: 32415-91-1(Hazardous Substances Data)

Usage

General Description

"2-Thiophenecarbonitrile,5-Fluoro-" is a chemical compound often utilized in the field of organic synthetic chemistry. 2-THIOPHENECARBONITRILE,5-FLUORO- falls into the category of organofluorides and organosulfurs. It identifies with the Molecular Formula of C5H2FNS and carries a Molecular Weight of 131.14 g/mol. This chemical exhibits a marked characteristic for fluorine substitution which makes it a useful component in various chemical reactions. The information about its physical characteristics such as density, boiling point or melting point might be scarce due to its specialized use. Furthermore, proper precautions should be taken while handling this chemical due to its potential toxicity.

Upstream product

• 16689-02-4 5-nitro-2-thienyl cyanide 
• 2751-90-8 tetraphenylphosphonium bromide 
• 88-95-9 Phthaloyl dichloride 

Downstream Products

• 761454-58-4 5-(4-formylphenoxy)thiophene-2-carbonitrile 
• 4377-58-6 5-fluorothiophene-2-carboxylic acid 
• 207849-74-9 (5-fluorothiophen-2-yl)formyl chloride 

Relevant articles and documents

An improved synthesis of 5-fluorothiophene-2-carboxylic acid

A new and efficient route to 5-fluorothiophene-2-carboxylic acid 1 was secured in two steps and 62% yield overall.

Thiophene and bioisostere derivatives as new MMP12 inhibitors

A new MMP12 inhibitor series has been identified containing a thiophene moiety. Different approaches have been considered to replace this potential toxicophore. α-Fluorothiophene derivatives were the most interesting compounds. Their synthesis is presente

Processes and intermediates for preparing 2-fluorothiophene derivatives

PCT No. PCT/IB98/00304 Sec. 371 Date Jul. 26, 1999 Sec. 102(e) Date Jul. 26, 1999 PCT Filed Mar. 9, 1998 PCT Pub. No. WO98/45282 PCT Pub. Date Oct. 15, 1998A process for the preparation of the compound of the formula wherein R1 is OH, which comprises the steps of a) treating the compound of the formula with an inorganic fluoride, of the formula M2F wherein M2 is an alkali metal cation, at an elevated temperature in the presence of a compound of the formula R4P+Z- and a compound of the formula R5vic (COW)2 wherein R4 and R5 are each selected from optionally substituted (C6-C10)aryl and optionally substituted (C1-C6)alkyl, and W is halo; to form the compound of the formula; and b) i) treating the compound of the formula IV with an aqueous solution of a base, of the formula MOH, wherein M is an alkali metal cation, and ii) treating the product of step i) with a mineral acid. A compound of the formula wherein R1 is selected from the group consisting of, halo, R7O, R7COO and N(R8)2 wherein R7 is (C1-C6)alkyl or (C6-C10)aryl and each R8 is selected from hydrogen and R7 with the proviso that R7 is not methyl when R1 is R7O.