4377-58-6

Basic information

• Product Name: 5-FLUORO-2-THIOPHENECARBOXYLIC ACID
• Synonyms: 5-FLUORO-2-THIOPHENECARBOXYLIC ACID;AKOS B029946;5-Fluoro-thiophene-2-carboxylic acid;5-Fluoro-thiophene-2-carb...;2-Thiophenecarboxylicacid, 5-fluoro-;5-Fluorothiophen-2-carboxylic acid;4-fluorothiophene-2-carboxylic acid;4-fluorothiop
• CAS NO: 4377-58-6
• Molecular Formula: C₅H₃FO₂S
• Molecular Weight: 146.14
• Mol File: 4377-58-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 139-141℃
• Boiling Point: 271.178 °C at 760 mmHg
• Flash Point: 117.804 °C
• Appearance: /
• Density: 1.528 g/cm³
• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.574
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 3.52±0.10(Predicted)
• CAS DataBase Reference: 5-FLUORO-2-THIOPHENECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-FLUORO-2-THIOPHENECARBOXYLIC ACID(4377-58-6)
• EPA Substance Registry System: 5-FLUORO-2-THIOPHENECARBOXYLIC ACID(4377-58-6)

Safety Data

• Hazardous Substances Data: 4377-58-6(Hazardous Substances Data)

Usage

General Description

5-Fluoro-2-thiophenecarboxylic Acid is an organic compound classified under the family of Thiophenecarboxylic Acids and derivatives. It is also known by other synonyms like Thiophene-2-carboxylic acid and 5-fluoro etc. This chemical consists of a thiophene ring, which contains a fluorine atom at the 5th carbon and a carboxylic acid group at the 2nd carbon. It appears as a beige to dark brown powder or crystalline solid. The chemical is used frequently as a reagent in various chemical reactions including the production of other complex organic compounds in pharmaceuticals, agrochemicals, and in dyestuff fields. The safety and handling measures of the chemical need to be stringently followed due to its potential hazards.

InChI:InChI=1/C5H3FO2S/c6-4-2-1-3(9-4)5(7)8/h1-2H,(H,7,8)

Upstream product

• 32415-91-1 5-fluorothiophene-2-carbonitrile 
• 16689-02-4 5-nitro-2-thienyl cyanide 

Downstream Products

• 207849-74-9 (5-fluorothiophen-2-yl)formyl chloride 
• 1463484-84-5 N-[5-allyl-6a-(5-fluoro-2-thienyl)-3,3a,4,6-tetrahydropyrrolo[3,4-c]isoxazole-1-carbothioyl]benzamide 
• 1463484-87-8 N-[[1-allyl-3-(5-fluoro-2-thienyl)-4-(hydroxymethyl)pyrrolidin-3-yl]carbamothioyl]benzamide 
• 1463485-13-3 N-[(4aR,7aR)-7a-(5-fluorothiophen-2-yl)-4,4a,5,6,7,7a-hexahydropyrrolo[3,4-d][1,3]thiazin-2-yl]benzamide 
• 1463485-27-9 N-[(4aR,7aR)-7a-(5-fluorothiophen-2-yl)-6-(pyrimidin-2-yl)-4,4a,5,6,7,7a-hexahydropyrrolo[3,4-d][1,3]thiazin-2-yl]benzamide 
• 1463485-28-0 N-[(4aR,7aR)-6-(5-fluoropyrimidin-2-yl)-7a-(5-fluorothiophen-2-yl)-4,4a,5,6,7,7a-hexahydropyrrolo[3,4-d][1,3]thiazin-2-yl]benzamide 
• 1463486-20-5 N-[(4aR,7aR)-7a-(5-fluorothiophen-2-yl)-6-(prop-2-en-1-yl)-4,4a,5,6,7,7a-hexahydropyrrolo[3,4-d][1,3]thiazin-2-yl]benzamide 
• 29669-49-6 5-fluorothiophene-2-carbaldehyde 

Relevant articles and documents

INHIBITOR OF CASEIN KINASE 1DELTA AND CASEIN KINASE 1E

There is provided a novel oxazolone derivative having inhibitory activity against casein kinase 1δ and casein kinase 1ε. In addition, the present inhibitor inhibits casein kinase 1δ and casein kinase 1ε, and thus there is also provided a pharmaceutical agent useful for the treatment and/or prevention of diseases, with the pathological conditions of which the activation mechanism of casein kinase 1δ or casein kinase 1ε is associated. There is further provided a pharmaceutical agent useful for the treatment of particularly, circadian rhythm disorder (including sleep disorder), central neurodegenerative disease, and cancer. An inhibitor of casein kinase 1δ and casein kinase 1ε comprising, as an act ingredient, an oxazolone derivative represented by the following general formula (1), a salt thereof, a solvate thereof, or a hydrate thereof: wherein X represents a halogen atom (which may be any one of a fluorine atom, a chlorine atom, a bromine atom, and an iodine atom).

Processes and intermediates for preparing 2-fluorothiophene derivatives

A process for the preparation of the compound of the formula: wherein R1 is OH, which comprises the steps of a) treating the compound of the formula: with an inorganic fluoride, of the formula M2F wherein M2 is an alkali metal cation, at an elevated temperature in the presence of a compound of the formula R4P+Z- and a compound of the formula R5vic (COW)2 wherein R4 and R5 are each selected from optionally substituted (C6-C10) aryl and optionally substituted (C1-C6) alkyl, and W is halo; to form the compound of the formula: and b) I) treating the compound of the formula IV with an aqueous solution of a base, of the formula MOH, wherein M is an alkali metal cation, and ii) treating the product of step i) with a mineral acid. A compound of the formula: wherein R1 is selected from the group consisting of, halo, R7O, R7COO and N(R8)2 wherein R7 is (C1-C6)alkyl or (C6-C10)aryl and each R8 is selected from hydrogen and R7 with the proviso that R7 is not methyl when R1 is R7O.