32428-69-6

Basic information

• Product Name: 2-BROMO-N-(2-METHOXY-PHENYL)-ACETAMIDE
• Synonyms: 2-BROMO-N-(2-METHOXY-PHENYL)-ACETAMIDE;AKOS BB/0136;CHEMBRDG-BB 4023684;AKOS BBB/488;acetamide, 2-bromo-N-(2-methoxyphenyl)-;2-bromo-N-(2-methoxyphenyl)acetamide(SALTDATA: FREE);2-bromo-N-(2-methoxyphenyl)ethanamide;ALD-N013250
• CAS NO: 32428-69-6
• Molecular Formula: C9H10BrNO2
• Molecular Weight: 244.09
• Mol File: 32428-69-6.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 351.9 °C at 760 mmHg
• Flash Point: 166.7 °C
• Appearance: /
• Density: 1.528 g/cm³
• Vapor Pressure: 3.97E-05mmHg at 25°C
• Refractive Index: 1.604
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-BROMO-N-(2-METHOXY-PHENYL)-ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-N-(2-METHOXY-PHENYL)-ACETAMIDE(32428-69-6)
• EPA Substance Registry System: 2-BROMO-N-(2-METHOXY-PHENYL)-ACETAMIDE(32428-69-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 32428-69-6(Hazardous Substances Data)

Usage

General Description

2-Bromo-N-(2-methoxy-phenyl)-acetamide, also known as 2-Bromo-2'-methoxyacetanilide, is a chemical compound with the molecular formula C10H12BrNO2. It is a white to off-white crystalline powder with a molecular weight of 261.11 g/mol. 2-BROMO-N-(2-METHOXY-PHENYL)-ACETAMIDE is commonly used as an intermediate in the synthesis of pharmaceuticals and organic compounds. It is also known for its potential use as a drug for the treatment of a variety of medical conditions, including pain and inflammation. 2-Bromo-N-(2-methoxy-phenyl)-acetamide is a regulated substance, and its handling and use must comply with all relevant safety and regulatory requirements.

InChI:InChI=1/C9H10BrNO2/c1-13-8-5-3-2-4-7(8)11-9(12)6-10/h2-5H,6H2,1H3,(H,11,12)

Upstream product

• 22118-09-8 2-bromoacetyl chloride 
• 90-04-0 2-methoxy-phenylamine 
• 598-21-0 2-Bromoacetyl bromide 

Downstream Products

• 892454-22-7 2-[{5-(4-nitrophenyl)-1,3,4-oxadiazole-2-yl}sulphanyl]-N-(2-methoxyphenyl)acetamide 
• 1582875-87-3 N-(2-methoxyphenyl)-2-[(phenylsulfonyl)(piperidin-1-yl)amino]acetamide 
• 83408-88-2 2-<(o-Methoxyphenylacetamido)mercapto>benzimidazole 
• 1310460-15-1 2-(3-benzoyl-4-hydroxy-1,1-dioxido-2H-benzo[e][1,2]thiazin-2-yl)-N-(2-methoxyphenyl)acetamide 

Relevant articles and documents

Synthesis and Antifungal Activity of New N-Aryl-2-(2-hydroxyphenylamino)ethylenediamine Derivatives

Abstract: In this study, a series of new N-aryl-2-(2-hydroxyphenylamino)ethylenediamine derivatives has beendesigned, synthesized and evaluated for antifungal activity against six selectedspecies of phytopathogenic fungi. Among the products, the most potent compoundhave demonstrated 97.7% inhibitory activity against S.sclerotiorum at the concentration of 50 μg/mL, which is higherthan that of the positive control chlorothalonil.

A novel method for the synthesis of 1,2,4-triazole-derived heterocyclic compounds: enzyme inhibition and molecular docking studies

Two series of new N-aryl/aralkyl derivatives (9a–q) of 2-(4-ethyl-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-ylthio)acetamide and N-aryl/aralkyl derivatives (10a–q) of 2-(4-phenyl-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-ylthio)acetamide were synthesized. The methods included successive conversions of thiophen-2-acetic acid (a) into its respective ester, hydrazide and N-aryl/aralkyl 1,3,4-triazole. The target compounds (9a–q; 10a–q) were obtained by the reaction of N-aryl/aralkyl 1,3,4-triazole (5, 6) with various electrophiles, (8a–q), in N,N-dimethyl formamide (DMF) and sodium hydroxide at room temperature. The characterization of these compounds was done by FTIR, 1H-, 13C-NMR, EI-MS and HR-EI-MS spectral data. All compounds were evaluated for their enzyme inhibitory potentials against electric eel acetylcholinesterase, AChE (10f, 10d; IC50 values 32.26 ± 0.12, 45.72 ± 0.11?μM, respectively), equine butyrylcholinesterase, BChE (9d, 9l, 9b, 10d, 10h; IC50 values 12.52 ± 0.19, 12.52 ± 0.19, 21.72 ± 0.18, 23.62 ± 0.22, 24.52 ± 0.21?μM, respectively), jack bean urease (10i, 10n, 9e; IC50 values 7.27 ± 0.05, 7.35 ± 0.04, 8.79 ± 0.05?μM, respectively) and yeast α-glucosidase enzymes (9o, 10i; IC50 values 62.94 ± 0.19, and 69.46 ± 0.15?μM, respectively). The molecular docking studies supported these findings. This study provides cheaper bioactive triazole amides as promising future lead molecules.

Design, synthesis, fungicidal activity and molecular docking studies of novel 2-((2-hydroxyphenyl)methylamino)acetamide derivatives

A series of novel 2-hydroxyphenyl substituted aminoacetamides was designed by molecular hybridization of the aminoacetamide scaffold and 2-hydroxyphenyl motif. The target compounds were synthesized and their fungicidal activities were evaluated. Some of the target compounds showed excellent antifungal activities against S. sclerotiorum and P. capsici. Significantly, compounds 5e displayed the most potent activity against S. sclerotiorum with EC50 = 2.89 μg/mL, which was lower than that of commercial chlorothalonil. The systematic studies provided strong confidence that the hydroxyl group and the carbonyl group are crucial for the fungicidal activity. Molecular docking studies suggest that SDH enzyme could be one of the potential action targets of our compounds.