3261-62-9

Basic information

• Product Name: 4-Methylphenethylamine
• Synonyms: RARECHEM AL BW 0059;P-METHYLPHENETHYLAMINE;4-METHYLPHENETHYLAMINE;2-(P-TOLYL)ETHYLAMINE;2-(4-Methylphenyl)ethanamine;Benzeneethanamine, 4-methyl-;2-(P-TOLYL)ETHYLAMINE 97%;4-METHYLPHENETHYLAMIN
• CAS NO: 3261-62-9
• Molecular Formula: C₉H₁₃N
• Molecular Weight: 135.21
• EINECS: 221-865-2
• Mol File: 3261-62-9.mol
• Article Data: 17

Chemical Properties

• Melting Point: 116°C (estimate)
• Boiling Point: 214 °C(lit.)
• Flash Point: 195 °F
• Appearance: Clear colorless to light yellow/Liquid
• Density: 0.93 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.159mmHg at 25°C
• Refractive Index: n20/D 1.527(lit.)
• PKA: 10.02±0.10(Predicted)
• CAS DataBase Reference: 4-Methylphenethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methylphenethylamine(3261-62-9)
• EPA Substance Registry System: 4-Methylphenethylamine(3261-62-9)

Safety Data

• Hazard Codes: Xi,C
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-37/39
• RIDADR: UN 2922 8/6.1/PG II
• WGK Germany: 3
• RTECS: DA0306700
• HazardClass: CORROSIVE
• PackingGroup: II
• Hazardous Substances Data: 3261-62-9(Hazardous Substances Data)

Usage

Description

4-Methylphenethylamine, also known as 2-(p-Tolyl)ethylamine, is an organic compound with the chemical formula C8H11N. It is a clear colorless to light yellow liquid at room temperature and is derived from the amidation of sophorolipid ethyl ester.

Uses

Used in Chemical Synthesis:
4-Methylphenethylamine is used as a chemical intermediate for the preparation of secondary amides. It plays a crucial role in the amidation of sophorolipid ethyl ester, which is an important step in the synthesis of various chemical compounds.
Used in Pharmaceutical Industry:
Although not explicitly mentioned in the provided materials, 4-Methylphenethylamine, due to its amine functional group, could potentially be used in the pharmaceutical industry for the synthesis of various drugs and medications. Amines are known to be versatile building blocks in the development of pharmaceutical compounds.
Used in Research and Development:
4-Methylphenethylamine may also find applications in research and development, particularly in the field of organic chemistry and material science. Its unique chemical properties could be exploited to create new compounds or materials with specific characteristics and applications.

InChI:InChI=1/C9H13N/c1-8-2-4-9(5-3-8)6-7-10/h2-5H,6-7,10H2,1H3/p+1

Upstream product

• 2947-61-7 (4-methylphenyl)acetonitrile 
• 6529-51-7 2-(4-methylphenyl)ethyl bromide 
• 2742-70-3 Bis-((E)-2-p-tolyl-vinyl)-diazene N,N'-dioxide 
• 7559-36-6 4-methyl-β-nitrostyrene 
• 72538-33-1 2-p-tolylnitroethane 
• 74533-76-9 3-(4-methylphenyl)propanamide 
• 861018-73-7 2-(4-methylphenethyl)isoindoline-1,3-dione 
• 64-17-5 ethanol 
• 622-75-3 1,4-phenylenediacetonitrile 
• 291301-31-0 C₁₉H₁₇N₃O 
• 101671-00-5 (Z)-1-methyl-4-(2-nitrovinyl)benzene 
• 104-87-0 4-methyl-benzaldehyde 
• 699-02-5 4-Methylphenethyl alcohol 
• 6749-78-6 4-methylphenylmagnesium iodide 

Downstream Products

• 699-02-5 4-Methylphenethyl alcohol 
• 76833-31-3 2-(4-methyl-cyclohexyl)-ethylamine 
• 108878-45-1 N-(4-methyl-phenethyl)-β-alanine nitrile 
• 26011-73-4 N-[2-(p-tolyl)ethyl] acetamide 
• 86427-24-9 3-(N-p-tolylethyliminomethyl)indole 
• 89516-38-1 2-acetyl-10-(p-tolylethylaminoacetyl)phenothiazine 
• 80554-84-3 2-(1H-Indol-3-yl)-2-oxo-N-(2-p-tolyl-ethyl)-acetamide 
• 80554-79-6 2-(2-Methyl-1H-indol-3-yl)-2-oxo-N-(2-p-tolyl-ethyl)-acetamide 
• 129397-53-1 N-Amoc-DL-α-methyl tryptophanyl-2-(4-methylphenyl)ethylamide 
• 80654-59-7 (4,4-Diphenyl-butyl)-(2-p-tolyl-ethyl)-amine 
• 112697-20-8 [6-Methylsulfanyl-1-(tetrahydro-furan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-(2-p-tolyl-ethyl)-amine 
• 86886-26-2 (E)-3-(2,4-Dihydroxy-6-methyl-pyrimidin-5-yl)-N-(2-p-tolyl-ethyl)-acrylamide 
• 80884-15-7 3-(4-Methoxy-phenyl)-2-[(2-p-tolyl-ethylamino)-methyl]-3H-quinazolin-4-one 
• 95833-39-9 6-Iodo-3-(4-methoxy-phenyl)-2-[(2-p-tolyl-ethylamino)-methyl]-3H-quinazolin-4-one 

Relevant articles and documents

Reduction of Aliphatic and Aromatic Nitro Compounds with Sodium Borohydride in Tetrahydrofuran Using 10percent Palladium-on-Carbon as Catalyst

Aliphatic and aromatic nitro compounds are reduced to amino compounds in good yields with sodium borohydride in tetrahydrofuran using 10percent palladium-on-carbon as catalyst.

Benzimidazole fragment containing Mn-complex catalyzed hydrosilylation of ketones and nitriles

The synthesis of a new bidentate (NN)–Mn(I) complex is reported and its catalytic activity towards the reduction of ketones and nitriles is studied. On comparing the reactivity of various other Mn(I) complexes supported by benzimidazole ligand, it was observed that the Mn(I) complexes bearing 6-methylpyridine and benzimidazole fragments exhibited the highest catalytic activity towards monohydrosilylation of ketones and dihydrosilylation of nitriles. Using this protocol, a wide range of ketones were selectively reduced to the corresponding silyl ethers. In case of unsaturated ketones, the chemoselective reduction of carbonyl group over olefinic bonds was observed. Additionally, selective dihydrosilylation of several nitriles were also achieved using this complex. Mechanistic investigations with radical scavengers suggested the involvement of radical species during the catalytic reaction. Stoichiometric reaction of the Mn(I) complex with phenylsilane revealed the formation of a new Mn(I) complex.

Combined Photoredox/Enzymatic C?H Benzylic Hydroxylations

Chemical transformations that install heteroatoms into C?H bonds are of significant interest because they streamline the construction of value-added small molecules. Direct C?H oxyfunctionalization, or the one step conversion of a C?H bond to a C?O bond, could be a highly enabling transformation due to the prevalence of the resulting enantioenriched alcohols in pharmaceuticals and natural products,. Here we report a single-flask photoredox/enzymatic process for direct C?H hydroxylation that proceeds with broad reactivity, chemoselectivity and enantioselectivity. This unified strategy advances general photoredox and enzymatic catalysis synergy and enables chemoenzymatic processes for powerful and selective oxidative transformations.