32766-61-3

Basic information

• Product Name: Methyl 2-(4-methoxyphenyl)-2-oxoacetate
• Synonyms: Methyl 2-(4-methoxyphenyl)-2-oxoacetate;4-Methoxy-oxo-benzeneacetic acid methyl ester
• CAS NO: 32766-61-3
• Molecular Formula: C₁₀H₁₀O₄
• Molecular Weight: 194.184
• Mol File: 32766-61-3.mol
• Article Data: 62

Chemical Properties

• Melting Point: 54 °C
• Boiling Point: 303.2±25.0 °C(Predicted)
• Appearance: /
• Density: 1.177±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Methyl 2-(4-methoxyphenyl)-2-oxoacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-(4-methoxyphenyl)-2-oxoacetate(32766-61-3)
• EPA Substance Registry System: Methyl 2-(4-methoxyphenyl)-2-oxoacetate(32766-61-3)

Safety Data

• Hazardous Substances Data: 32766-61-3(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 7099-91-4 p-methoxybenzoylformic acid 
• 23786-14-3 4-methoxy-phenyl acetic acid methyl ester 
• 6889-78-7 4'-(methoxy)-3-hydroxyflavone 
• 6971-17-1 3-hydroxy-2-(4-methoxy-phenyl)-6-methyl-chromen-4-one 
• 13305-14-1 methyl 2-hydroxy-2-(4-methoxyphenyl)acetate 
• 5781-53-3 monomethyl oxalyl chloride 
• 100-66-3 methoxybenzene 
• 17640-25-4 methyl 2,2-dichloro-2-methoxyacetate 
• 170166-55-9 2,2-Bis-benzotriazol-1-yl-2-methoxy-1-(4-methoxy-phenyl)-ethanone 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 6832-17-3 2-diazo-1-(4-methoxyphenyl)ethanone 
• 93296-09-4 4-methoxyphenylzinc chloride 
• 82303-13-7 (4-methoxyphenyl)zinc(II) bromide 

Downstream Products

• 156-38-7 4-hydroxyphenylacetate 
• 33131-26-9 2-(4-Methoxy-phenyl)-3-methyl-but-2-enoic acid methyl ester 
• 104206-34-0 methyl (E)-α-<3-methoxy-5-oxo-4-(3,4,5-trimethoxyphenyl)-2,5-dihydrofuran-2-ylidene>(4-methoxyphenyl)acetone 
• 61418-15-3 methyl (Z)-α-<3-methoxy-5-oxo-4-(3,4,5-trimethoxyphenyl)-2,5-dihydrofuran-2-ylidene>(4-methoxyphenyl)acetone 
• 137531-85-2 (Z)-O-methylisopinastric acid 
• 22628-24-6 (E)-4-methoxy-5-(α-methoxycarbonyl-4-methoxybenzylidene)-3-phenylfuran-2(5H)-one 
• 104383-29-1 methyl (S)-α-hydroxy-(4-methoxyphenyl)acetate 
• 32174-38-2 methyl (R)-2-hydroxy-2-(4-methoxyphenyl)acetate 
• 81316-44-1 trans-2,3-bis(carbomethoxy)-p,p'-dimethoxystilbene oxide 
• 81316-37-2 cis-2,3-bis(carbomethoxy)-p,p'-dimethoxystilbene oxide 
• 75334-99-5 2,2-Dimethoxy-2-(4-methoxyphenyl)essigsaeure-methylester 
• 248582-65-2 methyl (Z)-O-methyloximino-2-(4-methoxy)phenylacetate 
• 13305-14-1 methyl 2-hydroxy-2-(4-methoxyphenyl)acetate 
• 850794-55-7 methyl 2-(4-methoxyphenyl)-2,3-epoxypropanoate 

Relevant articles and documents

Unraveling two pathways for NHPI-mediated electrocatalytic oxidation reaction

Two pathways for N-hydroxyphthalimide (NHPI)-mediated electrocatalytic oxidation using phenylacetate derivatives as template substrates were first reported for benzylic C[sbnd]H oxidation to oxygenated and non-oxygenated products. DFT calculation indicates that the hydrogen-atom transfer (HAT) process between phthalimido-N-oxyl (PINO) and substrate is a rate-determined step. Aromatic α-keto esters and 2-((1,3-dioxoisoindolin-2-yl)oxy)-2-aryl acetate obtained by cross-coupling between benzylic radical and PINO can be selectively synthesized through controlling the concentration of PINO radical. This method provides a deep understanding for selective weak C[sbnd]H oxidation using NHPI as redox mediator.

Photoinduced Diverse Reactivity of Diazo Compounds with Nitrosoarenes

A diverse reactivity of diazo compounds with nitrosoarene in an oxygen-transfer process and a formal [2 + 2] cycloaddition is reported. Nitosoarene has been exploited as a mild oxygen source to oxidize an in situ generated carbene intermediate under visible-light irradiation. UV-light-mediated in situ generated ketenes react with nitosoarenes to deliver oxazetidine derivatives. These operationally simple processes exemplify a transition-metal-free and catalyst-free protocol to give structurally diverse α-ketoesters or oxazetidines.

Visible-Light-Induced Catalyst-Free Carboxylation of Acylsilanes with Carbon Dioxide

Intermolecular carbon-carbon bond formation between acylsilanes and carbon dioxide (CO2) was achieved by photoirradiation under catalyst-free conditions. In this reaction, siloxycarbenes generated by photoisomerization of the acylsilanes added to the C═O bond of CO2 to give α-ketocarboxylates, which underwent hydrolysis to afford α-ketocarboxylic derivatives in good yields. Control experiments suggest that the generated siloxycarbene is likely to be from the singlet state (S1) of the acylsilane and the addition to CO2 is not in a concerted manner.