332016-46-3

Basic information

• Product Name: 2-amino-N-(2-methoxyphenyl)acetamide
• Synonyms: 2-amino-N-(2-methoxyphenyl)acetamide
• CAS NO: 332016-46-3
• Molecular Formula: C₉H₁₂N₂O₂
• Molecular Weight: 180.20378
• Mol File: 332016-46-3.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-amino-N-(2-methoxyphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-N-(2-methoxyphenyl)acetamide(332016-46-3)
• EPA Substance Registry System: 2-amino-N-(2-methoxyphenyl)acetamide(332016-46-3)

Safety Data

• Hazardous Substances Data: 332016-46-3(Hazardous Substances Data)

Usage

Appearance

White to light yellow crystalline

Usage

Pharmaceutical development, research and development, building block/intermediate in organic synthesis

Therapeutic potential

Interaction with biological targets, key component in medicinal chemistry and drug discovery

Safety precautions

Handle with caution, follow proper safety protocols due to potential hazards and risks

Upstream product

• 55860-22-5 2-chloro-N-(2-methoxyphenyl)acetamide 
• 90-04-0 2-methoxy-phenylamine 
• 332016-44-1 [(2-methoxy-phenylcarbamoyl)-methyl]-carbamic acid tert-butyl ester 
• 133010-40-9 N-(2-methoxyphenyl)-2-[(phenylmethoxy)carbonylamino]ethanamide 

Downstream Products

• 36908-21-1 N¹-(2-methoxy-phenyl)-ethane-1,2-diamine 
• 696606-54-9 N-(2-methoxyphenyl)-2-[(triphenylmethylthio)methylcarbonylamino]ethanamide 
• 332016-47-4 thiobenzoic acid S-{[2-(2-methoxy-phenylamino)-ethylcarbamoyl]-methyl} ester 
• 160692-67-1 N-(2-(2-methoxyphenylamino)-2-oxoethyl)benzamide 
• 1172132-90-9 2-diazo-N-(2-methoxyphenyl)acetamide 

Relevant articles and documents

N-transfer reagent and method for preparing the same and its application

Provided are a novel N-transfer reagent and a method for preparing the same and its application. The N-transfer reagent is represented by the following Formula (I): The various novel N-transfer reagents of the present invention can be quickly prepared by employing different nitrobenzene precursors. The N-transfer reagents can directly convert a variety of amino compounds into diazo compounds under mild conditions. Particularly, the N-transfer reagents can facilitate the synthesis of the diazo compounds. The application of synthesizing diazo compounds of the present invention can greatly decrease the difficulty in operation, increase the safety during experiments, reduce the cost of production and the environmental pollution, and enhance the industrial value of diazo compounds.

Synthesis and anticonvulsant activity of some N-(benzoyl)glycinanilide derivatives

Glycine is a major inhibitory neurotransmitter and recent studies have shown that certain lipophilic glycine derivatives demonstrate anticonvulsant activity in animal epilepsy models. On the other hand, anilide is another fruitful structure for designing potential anticonvulsant agents. Ameltolide, ralitoline and some phthalimide derivatives are the examples of anilide analogs with potent anticonvulsant activity. In this study, two key structural pharmacophores were combined and a series of N-benzoylglycinanilide derivatives were designed. Their anticonvulsant activities evaluated against maximal electroshock (MES) and subcutaneous metrazole seizure tests, whereas their neurotoxicity was examined by rotarod test. The preliminary screening results indicated that majority of the compounds were effective in the MES test. None of the compounds showed neurotoxicity according to the rotarod test at studied doses. The most active compound in the series is N-(2-((4-methoxyphenyl)amino)- 2-oxoethyl)benzamide (compound 8) which bearing 4-methoxy substituent on the N-phenyl ring.

Synthesis and Biological Evaluation of New 99mTc-N2S2 or 99mTc-N2SO Complexes as Radiopharmaceuticals

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