3328-68-5

Basic information

• Product Name: 5-Chloro-2-Hyroxy-4-Methylbenzaldehyde (5-Chloro-4-Methylsalicylaldehyde)
• Synonyms: 5-Chloro-2-Hyroxy-4-Methylbenzaldehyde (5-Chloro-4-Methylsalicylaldehyde);5-Chloro-2-Hyroxy-4-Methylbenzaldehyde
• CAS NO: 3328-68-5
• Molecular Formula: C₈H₇ClO₂
• Molecular Weight: 170.594
• Mol File: 3328-68-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 252.2 °C at 760 mmHg
• Flash Point: 106.3 °C
• Appearance: /
• Density: 1.335 g/cm³
• Vapor Pressure: 0.0123mmHg at 25°C
• Refractive Index: 1.615
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 5-Chloro-2-Hyroxy-4-Methylbenzaldehyde (5-Chloro-4-Methylsalicylaldehyde)(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloro-2-Hyroxy-4-Methylbenzaldehyde (5-Chloro-4-Methylsalicylaldehyde)(3328-68-5)
• EPA Substance Registry System: 5-Chloro-2-Hyroxy-4-Methylbenzaldehyde (5-Chloro-4-Methylsalicylaldehyde)(3328-68-5)

Safety Data

• Hazardous Substances Data: 3328-68-5(Hazardous Substances Data)

Usage

General Description

5-Chloro-2-Hydroxy-4-Methylbenzaldehyde, also known as 5-Chloro-4-Methylsalicylaldehyde, is a chemical compound used mainly for organic synthesis. Its molecular formula is C8H7ClO2 and it has a molar mass of 170.59 g/mol. The substance has a chlorine atom attached to a benzene ring, which also has a hydroxy group and a methyl group, with an aldehyde functional group at an adjacent position on the ring. It is typically found as a light beige/yellowish solid in appearance. It is recognized for its suitability for further chemical processing. Caution is recommended when handling this compound, as it may cause irritation to skin and eyes. It should be stored in a cool, well-ventilated area, away from oxidative agents.

InChI:InChI=1/C8H7ClO2/c1-5-2-8(11)6(4-10)3-7(5)9/h2-4,11H,1H3

Upstream product

• 59-50-7 4-Chloro-3-methylphenol 
• 67-66-3 chloroform 
• 100-97-0 hexamethylenetetramine 
• 15733-22-9 4-chloro-3-methyl phenol, sodium salt 
• 3411-03-8 3-Chlor-4-methyl-benzaldehyd 

Downstream Products

• 215124-37-1 N,N-dimethyl-O-(4-chloro-2-formyl-5-methylphenyl)thiocarbamate 
• 1204655-61-7 C₁₅H₁₂BrClO₂ 
• 1413932-73-6 (E)-3-(5-chloro-2-hydroxy-4-methylphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one 

Relevant articles and documents

Pd-Catalyzed Ortho C-H Hydroxylation of Benzaldehydes Using a Transient Directing Group

The direct Pd-catalyzed ortho C-H hydroxylation of benzaldehydes was achieved using 4-chloroanthranilic acid as the transient directing group, 1-fluoro-2,4,6-trimethylpyridnium triflate as the bystanding oxidant, and p-toluenesulfonic acid as the putative oxygen nucleophile. The unusual C-H chlorination and polyfluoroalkoxylation reactions signaled the importance of external nucleophiles to the outcome of Pd(IV) reductive eliminations.

Synthesis of substituted 2-hydroxyaryl aldehydes by the microwave-induced Reimer-Tiemann reaction

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CHROMENE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS

The subject invention concerns methods and compounds that have utility in the treatment of a condition associated with cyclooxygenase-2 mediated disorders. Compounds of particular interest are benzopyrans and their analogs defined by formula (I). Wherein Z, X, R1, R2, R3, and R4 are as described in the specification.