3408-21-7

Basic information

• Product Name: P 1052
• CAS NO: 3408-21-7
• Molecular Formula: C₁₀H₁₄N₂O
• Molecular Weight: 178.234
• Mol File: 3408-21-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 245.7°Cat760mmHg
• Flash Point: 91.6°C
• Density: 1.036g/cm³
• CAS DataBase Reference: P 1052(CAS DataBase Reference)
• NIST Chemistry Reference: P 1052(3408-21-7)
• EPA Substance Registry System: P 1052(3408-21-7)

Safety Data

• Hazardous Substances Data: 3408-21-7(Hazardous Substances Data)

Upstream product

• 613-94-5 benzoic acid hydrazide 
• 108-18-9 diisopropylamine 

Downstream Products

• 1407499-67-5 (E)-N'-(3-(1-cyclopropyl-1H-indol-3-yl)acryloyl)-N'-isopropylbenzohydrazide 
• 1407499-64-2 (E)-N'-(3-(1-benzyl-1H-indol-3-yl)acryloyl)-N'-isopropylbenzohydrazide 
• 1407499-69-7 (E)-N'-isopropyl-N'-(3-(1-pivaloyl-1H-indol-3-yl)acryloyl)benzohydrazide 
• 1407499-68-6 (E)-N'-(3-(1-acetyl-1H-indol-3-yl)acryloyl)-N'-isopropylbenzohydrazide 
• 1407499-66-4 (E)-N'-(3-(1-(cyclopropylmethyl)-1H-indol-3-yl)acryloyl)-N'-isopropylbenzohydrazide 
• 1407499-65-3 (E)-N'-isopropyl-N'-(3-(1-(3-methylbut-2-enyl)-1H-indol-3-yl)acryloyl)benzohydrazide 
• 1407499-63-1 (E)-N'-isopropyl-N'-(3-(1-methyl-1H-indol-3-yl)acryloyl)benzohydrazide 
• 1407499-61-9 N'-(3-(1H-indol-3-yl)propanoyl)-N'-isopropylbenzohydrazide 
• 1407499-60-8 (E)-N'-(3-(1H-indol-3-yl)acryloyl)-N'-isopropylbenzohydrazide 
• 1407499-62-0 tert-butyl 3-(3-(2-benzoyl-1-isopropylhydrazinyl)-3-oxopropyl)-1H-indole-1-carboxylate 
• 1407499-59-5 N'-(3-(1-benzyl-1H-indol-3-yl)propanoyl)-N'-isopropylbenzohydrazide 
• 1407499-71-1 (E)-N'-(3-(1-(3,3-dimethylbutanoyl)-1H-indol-3-yl)acryloyl)-N'-isopropylbenzohydrazide 
• 1407499-70-0 (E)-N'-(3-(1-benzoyl-1H-indol-3-yl)acryloyl)-N'-isopropylbenzohydrazide 
• 1407499-39-1 (E)-tert-butyl 3-(3-(2-benzoyl-1-isopropylhydrazinyl)-3-oxoprop-1-enyl)-1H-indole-1-carboxylate 

Relevant articles and documents

Alkylation of Amines with Alcohols and Amines by a Single Catalyst under Mild Conditions

An efficient catalytic system for the alkylation of amines with either alcohols or amines under mild conditions has been developed, using cyclometallated iridium complexes as catalysts. The method has broad substrate scope, allowing for the synthesis of a diverse range of secondary and tertiary amines with good to excellent yields. By controlling the ratio of substrates, both mono- and bis-alkylated amines can be obtained with high selectivity. In particular, methanol can be used as the alkylating reagent, affording N-methylated products selectively. A strong solvent effect is observed for the reaction.

HDAC INHIBITOR COMPOUNDS AND METHODS OF TREATMENT

The instant invention describes hydrazide-containing compounds having therapeutic activity, and methods of treating disorders such as cancer, tumors and cell proliferation related disorders, or affect cell differentiation, dedifferentiation or transdiffer

An efficient synthesis of substituted hydrazides

Routes for the selective synthesis of 1-, or 2-substituted hydrazides, and 1,2-disubstituted hydrazides are reported. These routes proceed via cyanoborohydride reduction of stable acyl hydrazone intermediates. Georg Thieme Verlag Stuttgart.