34237-59-7

Basic information

• Product Name: Phenol, 4-(1,1-dimethylethyl)-2,6-dinitro-, 4-methylbenzenesulfonate (ester)
• CAS NO: 34237-59-7
• Molecular Formula: C17H18N2O7S
• Molecular Weight: 394.405
• Mol File: 34237-59-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Phenol, 4-(1,1-dimethylethyl)-2,6-dinitro-, 4-methylbenzenesulfonate (ester)(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 4-(1,1-dimethylethyl)-2,6-dinitro-, 4-methylbenzenesulfonate (ester)(34237-59-7)
• EPA Substance Registry System: Phenol, 4-(1,1-dimethylethyl)-2,6-dinitro-, 4-methylbenzenesulfonate (ester)(34237-59-7)

Safety Data

• Hazardous Substances Data: 34237-59-7(Hazardous Substances Data)

Upstream product

• 4097-49-8 4-tert-butyl-2,6-dinitrophenol 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 439948-77-3 2,6-dinitro-4-t-butyl-1-(2-t-bytoxycarbonylaminoethyl)-sulfanylbenzene 
• 439948-71-7 2,6-diamino-4-t-butyl-1-(2-t-butoxycarbonylaminoethyl)sulfanyl-benzene 

Relevant articles and documents

Arylamide derivatives as peptidomimetic inhibitors of calmodulin

Many peptides bind to calmodulin (CaM) in a helical conformation. Here we describe a group of synthetic inhibitors of CaM based on an arylamide scaffold that is intended to mimic smMLCK, a CaM-binding helical peptide. Compound 1 showed a Ki value of 7.10 ± 1.48 nM in a fluorescence polarization assay that monitors the strong association of CaM and its peptide ligand mastoparan X. (1H,15N)-HSQC NMR spectroscopy experiments suggested that 1 binds to CaM in an analogous fashion to that of smMLCK.

Arylamide derivatives as allosteric inhibitors of the integrin α2β1/type I collagen interaction

We herein report a group of allosteric inhibitors of integrin α2β1 based on an arylamide scaffold. Compound 4 showed an IC50 of 4.80 μM in disrupting integrin I-domain/collagen binding in an ELISA. These arylamide compound