439948-77-3

Basic information

• Product Name: Carbamic acid, [2-[[4-(1,1-dimethylethyl)-2,6-dinitrophenyl]thio]ethyl]-, 1,1-dimethylethyl ester
• CAS NO: 439948-77-3
• Molecular Formula: C17H25N3O6S
• Molecular Weight: 399.468
• Mol File: 439948-77-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [2-[[4-(1,1-dimethylethyl)-2,6-dinitrophenyl]thio]ethyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [2-[[4-(1,1-dimethylethyl)-2,6-dinitrophenyl]thio]ethyl]-, 1,1-dimethylethyl ester(439948-77-3)
• EPA Substance Registry System: Carbamic acid, [2-[[4-(1,1-dimethylethyl)-2,6-dinitrophenyl]thio]ethyl]-, 1,1-dimethylethyl ester(439948-77-3)

Safety Data

• Hazardous Substances Data: 439948-77-3(Hazardous Substances Data)

Upstream product

• 4097-49-8 4-tert-butyl-2,6-dinitrophenol 
• 67385-09-5 2-[(tert-butoxycarbonyl)amino]-1-ethanethiol 
• 34237-59-7 2,6-dinitro-4-t-butyl-phenyl (4-methyl)-benzenesulfonate 

Downstream Products

• 439948-71-7 2,6-diamino-4-t-butyl-1-(2-t-butoxycarbonylaminoethyl)sulfanyl-benzene 

Relevant articles and documents

Arylamide derivatives as allosteric inhibitors of the integrin α2β1/type I collagen interaction

We herein report a group of allosteric inhibitors of integrin α2β1 based on an arylamide scaffold. Compound 4 showed an IC50 of 4.80 μM in disrupting integrin I-domain/collagen binding in an ELISA. These arylamide compound

Arylamide derivatives as peptidomimetic inhibitors of calmodulin

Many peptides bind to calmodulin (CaM) in a helical conformation. Here we describe a group of synthetic inhibitors of CaM based on an arylamide scaffold that is intended to mimic smMLCK, a CaM-binding helical peptide. Compound 1 showed a Ki value of 7.10 ± 1.48 nM in a fluorescence polarization assay that monitors the strong association of CaM and its peptide ligand mastoparan X. (1H,15N)-HSQC NMR spectroscopy experiments suggested that 1 binds to CaM in an analogous fashion to that of smMLCK.