3430-19-1 Usage
Description
5-Methylpyridin-3-amine, also known as 3-Amino-5-methylpyridine, is an organic compound with the molecular formula C6H8N2. It is a heterocyclic aromatic amine derivative of pyridine, featuring a methyl group at the 5th position and an amino group at the 3rd position. 5-Methylpyridin-3-amine is known for its versatile chemical properties and wide range of applications across different industries.
Uses
Used in Pharmaceutical Industry:
5-Methylpyridin-3-amine is used as a pharmaceutical intermediate for the development of various drugs. Its unique chemical structure allows it to serve as a building block in the synthesis of complex medicinal compounds, contributing to the creation of novel therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, 5-Methylpyridin-3-amine is utilized as a key intermediate for the production of a wide array of organic compounds. Its reactivity and functional groups make it a valuable component in the synthesis of various organic molecules, including those with potential applications in materials science, agrochemicals, and specialty chemicals.
Used in Organic Solvents:
Due to its solubility and stability characteristics, 5-Methylpyridin-3-amine can be employed as an organic solvent in certain chemical reactions. It may be particularly useful in processes that require a polar, aprotic solvent, facilitating the dissolution of a wide range of substrates and improving the efficiency of the reaction.
Used in Dye Production:
5-Methylpyridin-3-amine is used in the production of dyes, where its chemical properties enable the creation of a diverse palette of colors. Its role in dye synthesis is crucial for the development of new dyes with improved properties, such as enhanced colorfastness, brightness, and resistance to fading.
Used in Pesticide Industry:
In the agricultural sector, 5-Methylpyridin-3-amine is used as a component in the formulation of pesticides. Its incorporation into pesticide formulations can enhance their effectiveness against various pests, leading to improved crop protection and increased agricultural productivity.
Used in Spices Production:
5-Methylpyridin-3-amine also finds application in the production of spices, where it can be used to create or enhance the flavor profiles of various spice blends. Its unique chemical structure allows it to contribute to the development of innovative and complex flavor combinations, enriching the culinary experience.
Synthesis
3-Amino-5-methylpyridine can be obtained by condensation reaction and decarboxylation reaction of diethyl malonate, sodium, 3-nitro-5-chloropyridine, and then reduction reaction.
Check Digit Verification of cas no
The CAS Registry Mumber 3430-19-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,4,3 and 0 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 3430-19:
(6*3)+(5*4)+(4*3)+(3*0)+(2*1)+(1*9)=61
61 % 10 = 1
So 3430-19-1 is a valid CAS Registry Number.
InChI:InChI=1/C6H8N2/c1-5-2-6(7)4-8-3-5/h2-4H,7H2,1H3
3430-19-1Relevant articles and documents
Synthesis method of 3-bromo-5-methylpyridine
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Paragraph 0025, (2017/10/07)
The invention relates to the field of organic chemistry and particularly provides a synthesis method of 3-bromo-5-methylpyridine. The synthesis method includes the steps of: 1) performing a reaction to diethyl malonate and alkaline metal to generate a salt, and dropwise adding a toluene solution of 3-nitro-5-chloropyridine to perform a condensation reaction, and decarboxylating the product under an acidic condition to obtain 3-nitro-5-methylpyridine; 2) performing hydrogenation reduction to the 3-nitro-5-methylpyridine with Pd/C as a catalyst and methanol as a solvent, performing suction filtration and concentrating a filtrate to prepare 3-amino-5-methylpyridine; and 3) performing a reaction to the 3-amino-5-methylpyridine with an acid to generate a salt, and cooling the salt to -10 - 0 DEG C, dropwise adding liquid bromine, and then dropwise adding a sodium nitrite water solution, regulating the pH value of the solution to alkalinity and performing extraction, drying and concentration to obtain the 3-bromo-5-methylpyridine. The synthesis method is mild in reaction conditions, is high in yield, employs easy-to-obtained raw materials, is low in cost, is short in process route and has industrial prospect.
COMPOSITIONS AND THERAPEUTIC USES OF IKK-RELATED KINASE EPSILON AND TANKBINDING KINASE 1 INHIBITORS
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Page/Page column 75, (2012/11/06)
The invention relates to compounds, pharmaceutical compositions and medicaments comprising such compounds, and the use of these compounds, compositions, and medicaments in methods of treating diseases and disorders.
Structure-activity studies of novel cyanoguanidine ATP-sensitive potassium channel openers for the treatment of overactive bladder
Perez-Medrano, Arturo,Brune, Michael E.,Buckner, Steven A.,Coghlan, Michael J.,Fey, Thomas A.,Gopalakrishnan, Murali,Gregg, Robert J.,Kort, Michael E.,Scott, Victoria E.,Sullivan, James P.,Whiteaker, Kristi L.,Carroll, William A.
, p. 6265 - 6273 (2008/04/05)
A series of novel cyanoguanidine derivatives was designed and synthesized. Condensation of N-(1-benzotriazol-1-yl-2,2-dichloropropyl)-substituted benzamides with N-(substituted-pyridin-3-yl)-N′-cyanoguanidines furnished N-{2,2-dichloro-1-[N′-(substituted-pyridin-3-yl)-N′-cyanoguanidino] propyl}-substituted benzamide derivatives. These agents were glyburide-reversible potassium channel openers and hyperpolarized human bladder cells as assessed by the FLIPR membrane potential dye (KATP-FMP). These compounds were also potent full agonists in relaxing electrically stimulated pig bladder strips, an in vitro model of overactive bladder. The most active compound 9 was evaluated for in vivo efficacy and selectivity in a pig model of bladder instability. Preliminary pharmacokinetic studies in dog demonstrated excellent oral bioavailability and a t1/2 of 15 h. The synthesis, SAR studies, and biological properties of these agents are discussed.