347-84-2

Basic information

• Product Name: 4'-FLUORO-2-PHENYLACETOPHENONE
• Synonyms: BENZYL 4-FLUOROPHENYL KETONE;4'-FLUORO-2-PHENYLACETOPHENONE;1-(4-FLUOROPHENYL)-2-PHENYLETHANONE;1-(4-Fluorophenyl)-2-phenylethanone 99%;1-(4-Fluorophenyl)-2-phenylethanone99%;1-(4-fluorophenyl)-2-phenylethan-1-one
• CAS NO: 347-84-2
• Molecular Formula: C₁₄H₁₁FO
• Molecular Weight: 214.23
• Product Categories: pharmacetical
• Mol File: 347-84-2.mol
• Article Data: 54

Chemical Properties

• Melting Point: 83-84
• Boiling Point: 332.9 °C at 760 mmHg
• Flash Point: 137.9 °C
• Appearance: /
• Density: 1.152 g/cm³
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 4'-FLUORO-2-PHENYLACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-FLUORO-2-PHENYLACETOPHENONE(347-84-2)
• EPA Substance Registry System: 4'-FLUORO-2-PHENYLACETOPHENONE(347-84-2)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 347-84-2(Hazardous Substances Data)

Usage

Description

4'-FLUORO-2-PHENYLACETOPHENONE, also known as 1-(4-Fluorophenyl)-2-phenyl-ethanone, is an organic compound that serves as a key intermediate in the synthesis of various pharmaceuticals and chemical compounds. It is characterized by the presence of a fluorophenyl and phenyl group attached to an ethanone moiety, which contributes to its unique chemical properties and reactivity.

Uses

Used in Pharmaceutical Industry:
4'-FLUORO-2-PHENYLACETOPHENONE is used as a chemical intermediate for the preparation of 2,3-diarylpyrazines and quinoxalines, which are selective COX-2 inhibitors. These inhibitors play a crucial role in the development of anti-inflammatory and analgesic drugs, as they help reduce inflammation and pain by targeting the specific enzyme responsible for prostaglandin synthesis.
In the synthesis of these compounds, 4'-FLUORO-2-PHENYLACETOPHENONE serves as a building block, providing the necessary structural elements for the formation of the desired molecules. Its presence in the final product contributes to the overall effectiveness and selectivity of the COX-2 inhibitors, making it an essential component in the development of new and improved pharmaceuticals for the treatment of various inflammatory and pain-related conditions.

Upstream product

• 462-06-6 fluorobenzene 
• 103-80-0 phenylacetyl chloride 
• 395-21-1 1-(4-fluorophenyl)-1-phenylethylene 
• 405-29-8 (4-fluorophenyl)phenylacetylene 
• 1600-27-7 mercury(II) diacetate 
• 532-27-4 1-chloroacetophenone 
• 352-13-6 4-flourophenylmagnesium bromide 
• 100-39-0 benzyl bromide 
• 403-43-0 4-fluorobenzoyl chloride 
• 1765-93-1 4-fluoroboronic acid 
• 140-29-4 phenylacetonitrile 
• 4747-15-3 1-(2-methoxyvinyl)benzene 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 103-82-2 phenylacetic acid 

Downstream Products

• 323-28-4 4-fluoro-deoxybenzoin semicarbazone 
• 436-02-2 2-(4-fluoro-phenyl)-3-phenyl-quinoline-4-carboxylic acid 
• 361-28-4 6-bromo-2-(4-fluoro-phenyl)-3-phenyl-quinoline-4-carboxylic acid 
• 436-53-3 2-(4-fluorophenyl)-3-phenyl-1H-indole 
• 60694-99-7 1-(4-cyanophenyl)-2-phenylethan-1-one 
• 88522-72-9 1-(4-fluoro-phenyl)-2-hydroxy-2-phenylethanone 
• 73424-43-8 1-(4-Fluorphenyl)-2-phenyl-1-ethanon-p-tolylsulfonylhydrazon 
• 23075-70-9 2-diazo-1-(4-fluorophenyl)-2-phenylethan-1-one 
• 31464-85-4 1-(4-Fluoro-phenyl)-2-{[2-(4-fluoro-phenyl)-2-oxo-1-phenyl-eth-(E)-ylidene]-hydrazono}-2-phenyl-ethanone 
• 88675-31-4 2-bromo-1-(4-fluorophenyl)-2-phenylethan-1-one 
• 185345-82-8 4-[2-(4-fluorophenyl)-2-oxoethyl]-1-benzenesulfonamide 
• 323-28-4 C₁₅H₁₄FN₃O 
• 445411-74-5 benzyl p-fluorophenyl ketoxime 
• 73424-52-9 4-(4-Fluorphenyl)-5-phenyl-1,2,3-thiadiazol 

Relevant articles and documents

Electrochemical oxidation-induced benzyl C–H carbonylation for the synthesis of aromatic α-diketones

Electrochemical oxidation-induced direct carbonylation of benzyl C–H bond for the synthesis of aromatic α-diketones is described. In this process, tetrabutylammonium iodide (nBu4NI) not only acts as an electrolyte, but its iodine anion is oxidized to an iodine radical at the anode, acting as a hydrogen atom transfer agent. The iodine radical extracts the benzyl hydrogen atom and causes the carbonylation of the benzyl position, where O2 in the air is used as an oxygen source.

METHOD OF PREPARING(3R,5R)-7-(2-(4-FLUOROPHENYL)-5-ISOPROPYL-3-PHENYL-4-((4-HYDROXYMETHYLPHENYLAMINO)CARBONYL)-PYRROL-1-YL)-3,5-DIHYDROXY-HEPTANOIC ACID HEMI CALCIUM SALT, AND METHOD OF PREPARING INTERMEDIATES USED THEREIN

The present invention provides a method for preparing (3R,5R)-7-(2-(4-flurophenyl)-5-isopropyl-3-phenyl-4-((4-hydroxymethylphenylamino)carbonyl)-pyrrole-1-yl)-3,5-dihydroxy heptanoic acid hemicalcium salt. The preparation method of the present invention is performed in a convergent synthesis manner in which main structural moieties of a (3R,5R)-7-(2-(4-flurophenyl)-5-isopropyl-3-phenyl-4-((4-hydroxymethylphenylamino)carbonyl)-pyrrole-1-yl)-3,5-dihydroxy heptanoic acid hemicalcium salt are independently synthesized, and then coupled. Accordingly, related substances can be easily controlled and preparing time can be reduced, thus improving the productivity of a compound, and the yield of a final compound can also be increased.

Iron-Catalyzed Enantioselective Radical Carboazidation and Diazidation of α,β-Unsaturated Carbonyl Compounds

Azidation of alkenes is an efficient protocol to synthesize organic azides which are important structural motifs in organic synthesis. Enantioselective radical azidation, as a useful strategy to install a C-N3 bond, remains challenging due to the inherently instability and unique structure of radicals. Here, we disclose an efficient enantioselective radical carboazidation and diazidation of α,β-unsaturated ketones and amides catalyzed by chiral N,N′-dioxide/Fe(OTf)2 complexes. An array of substituted alkenes was transformed to the corresponding α-azido carbonyl derivatives in good to excellent enantioselectivities, benefiting the preparation of chiral α-amino ketones, vicinal amino alcohols, and vicinal diamines. Control experiments and mechanistic studies proved the radical pathway in the reaction process. The DFT calculations showed that the azido transferred to the radical intermediate via an intramolecular five-membered transition state with the internal nitrogen of the Fe-N3 species.