3470-55-1

Basic information

• Product Name: 2-amino-6,7,8,9-tetrahydrobenzo[7]annulen-5-one
• Synonyms: 2-amino-6,7,8,9-tetrahydrobenzo[7]annulen-5-one;2-aMino-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-one
• CAS NO: 3470-55-1
• Molecular Formula: C₁₁H₁₃NO
• Molecular Weight: 175.23
• Mol File: 3470-55-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 113-114 °C
• Boiling Point: 370.1±31.0 °C(Predicted)
• Appearance: /
• Density: 1.146±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.22±0.20(Predicted)
• CAS DataBase Reference: 2-amino-6,7,8,9-tetrahydrobenzo[7]annulen-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-6,7,8,9-tetrahydrobenzo[7]annulen-5-one(3470-55-1)
• EPA Substance Registry System: 2-amino-6,7,8,9-tetrahydrobenzo[7]annulen-5-one(3470-55-1)

Safety Data

• Hazardous Substances Data: 3470-55-1(Hazardous Substances Data)

Usage

General Description

2-amino-6,7,8,9-tetrahydrobenzo[7]annulen-5-one is a chemical compound with a complex molecular structure. It is an amino derivative of tetrahydrobenzo[7]annulen-5-one, which is a benzocycloheptenone. 2-amino-6,7,8,9-tetrahydrobenzo[7]annulen-5-one is potentially important in medicinal and pharmaceutical chemistry due to its ability to interact with biological systems and potentially exhibit pharmacological effects. Its specific properties and potential applications would need to be further studied and understood in order to fully harness its potential benefits.

Upstream product

• 93431-20-0 5-(3-acetamidophenyl)pentanoic acid 
• 95207-74-2 2-(N-acetyl)amino-6,7,8,9-tetrahydrobenzo-cyclohepten-5-one 
• 93188-08-0 4-<3-Acetamino-benzoyl>-buttersaeure 
• 24127-36-4 2-chloro-6,7,8,9-tetrahydro-5H-benzocycloheptene-5-one 

Downstream Products

• 3470-51-7 2-hydroxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-one 
• 954152-10-4 C₂₅H₂₅NO 
• 24127-36-4 2-chloro-6,7,8,9-tetrahydro-5H-benzocycloheptene-5-one 
• 1049666-14-9 2,6-difluoro-N-(5-oxo-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl)-benzamide 

Relevant articles and documents

SUBSTITUTED POLYCYCLIC ANTIBACTERIAL COMPOUNDS

The present description relates to substituted polycyclic compounds and forms and pharmaceutical compositions thereof and methods of using such compounds, forms or compositions thereof for treating or ameliorating Neisseria gonorrhoeae and Neisseria meningiditis.

Selective κ-opioid agonists: Synthesis and structure-activity relationships of piperidines incorporating an oxo-containing acyl group

This study describes the synthesis and the structure-activity relationships (SARs) of the (S)-(-)-enantiomers of a novel class of 2- (aminomethyl)piperidine derivatives, using κ-opioid binding affinity and antinociceptive potency as the indices of biological activity. Compounds incorporating the 1-tetralon-6-ylacetyl residue (30 and 34-45) demonstrated an in vivo antinociceptive activity greater than predicted on the basis of their κ-binding affinities. In particular, (2S)-2-[(dimethylamino)methyl]- 1-[(5,6,7,8-tetrahydro-5-oxo-2-naphthyl)acetyl]piperidine (34) was found to have a potency similar to spiradoline in animal models of antinociception after subcutaneous administration, with ED50s of 0.47 and 0.73 μmol/kg in the mouse and in the rat abdominal constriction tests, respectively. Further in vivo studies in mice and/or rats revealed that compound 34, compared to other selective κ-agonists, has a reduced propensity to cause a number of κ-related side effects, including locomotor impairment/sedation and diuresis, at antinociceptive doses. For example, it has an ED50 of 26.5 μmol/kg sc in the rat rotarod model, exhibiting a ratio of locomotor impairment/sedation vs analgesia of 36. Possible reasons for this differential activity and its clinical consequence are discussed.