24127-36-4 Usage
Description
2-CHLORO-6,7,8,9-TETRAHYDRO-BENZOCYCLOHEPTEN-5-ONE is an organic compound that serves as a valuable building block in the synthesis of various chemical compounds, particularly cannabinoid 1 (CB1) antagonists. Its unique chemical structure allows for the development of new pharmaceuticals and therapeutic agents.
Uses
Used in Pharmaceutical Industry:
2-CHLORO-6,7,8,9-TETRAHYDRO-BENZOCYCLOHEPTEN-5-ONE is used as a key intermediate in the synthesis of cannabinoid 1 (CB1) antagonists for the pharmaceutical industry. These antagonists have potential applications in the treatment of various conditions, such as obesity, metabolic disorders, and neurological diseases, due to their ability to modulate the endocannabinoid system.
Used in Research and Development:
In the field of research and development, 2-CHLORO-6,7,8,9-TETRAHYDRO-BENZOCYCLOHEPTEN-5-ONE is utilized as a starting material for the creation of novel chemical entities. Its structural properties make it a versatile compound for exploring new drug candidates and understanding the underlying mechanisms of various diseases.
Used in Drug Design and Optimization:
2-CHLORO-6,7,8,9-TETRAHYDRO-BENZOCYCLOHEPTEN-5-ONE is employed as a structural component in drug design and optimization processes. Its incorporation into new molecular entities can lead to the development of more effective and selective CB1 antagonists, potentially improving the treatment of related conditions and reducing side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 24127-36-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,1,2 and 7 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 24127-36:
(7*2)+(6*4)+(5*1)+(4*2)+(3*7)+(2*3)+(1*6)=84
84 % 10 = 4
So 24127-36-4 is a valid CAS Registry Number.
24127-36-4Relevant articles and documents
Iridium/f-Amphol-catalyzed Efficient Asymmetric Hydrogenation of Benzo-fused Cyclic Ketones
Yin, Congcong,Dong, Xiu-Qin,Zhang, Xumu
, p. 4319 - 4324 (2018/10/15)
Iridium/f-Amphol-catalyzed asymmetric hydrogenation of various benzo-fused five to seven-membered cyclic ketones was successfully developed, affording a series of chiral benzo-fused cyclic alcohols with excellent results (75%–99% yields, 93%–>99% ee, and TON up to 297 000). The enantioenriched products can be employed as key intermediates or motifs for the synthesis of some important biologically active compounds, such as rasagiline mesylate TVP-1012 used for the treatment of Parkinson's disease, the enantiomer of anticonvulsant drug eslicarbazepine acetate (BIA 2-093). (Figure presented.).
HMG-CoA reductase inhibitors
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Page/Page column 93, (2010/11/28)
Compounds are provided of the following structure are HMG CoA reductase inhibitors and thus are active in inhibiting cholesterol biosynthesis, modulating blood serum lipids, for example, lowering LDL cholesterol and/or increasing HDL cholesterol, and trea
Pyrazolecarboxylic acid tricyclic derivatives, preparation and pharmaceutical compositions containing same
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Page/Page column 16-17, (2010/02/11)
The subject of the invention is tricyclic derivatives of pyrazolecarboxylic acid of formula: in which R1 represents a C3-C15 carboxyl radical or an NR2R3 group. The invention also relates to the method for preparing the compounds of formula (I), pharmaceutical compositions containing them. The compounds of formula (I) are active on cannabinoid CB1 receptors.
