348640-18-6

Basic information

• Product Name: 2-(5-Methoxy-1H-indol-3-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine
• Synonyms: 2-(5-Methoxy-1H-indol-3-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine;2-(5-Methoxy-1H-indol-3-yl)-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine
• CAS NO: 348640-18-6
• Molecular Formula: C₂₃H₁₉N₃O₃S
• Molecular Weight: 417.48026
• Mol File: 348640-18-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 698.041°C at 760 mmHg
• Flash Point: 375.962°C
• Appearance: /
• Density: 1.367g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.69
• CAS DataBase Reference: 2-(5-Methoxy-1H-indol-3-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(5-Methoxy-1H-indol-3-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine(348640-18-6)
• EPA Substance Registry System: 2-(5-Methoxy-1H-indol-3-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine(348640-18-6)

Safety Data

• Hazardous Substances Data: 348640-18-6(Hazardous Substances Data)

Usage

Core structure

2-(5-methoxy-1H-indol-3-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine has a complex structure with a pyrrolopyridine core.

Tosyl group

The compound has a tosyl group attached at one end, which is a sulfonate ester.

Methoxy-indolyl group

The compound has a methoxy-indolyl group at the other end, which contains a methoxy substituent.

Pharmaceutical applications

2-(5-methoxy-1H-indol-3-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine has potential pharmaceutical applications due to its unique structure and properties.

Medicinal chemistry research

The compound may be used in medicinal chemistry research for the development of new drugs targeting specific biological pathways or processes.

Materials science

The compound could be of interest in the field of materials science for the synthesis of novel organic compounds with advanced functions or properties.

InChI:InChI=1/C23H19N3O3S/c1-15-5-8-18(9-6-15)30(27,28)26-22(12-16-4-3-11-24-23(16)26)20-14-25-21-10-7-17(29-2)13-19(20)21/h3-14,25H,1-2H3

Upstream product

• 348640-10-8 2-iodo-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine 
• 348640-19-7 C₁₄H₁₈BNO₅ 
• 348640-02-8 1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridine 
• 271-63-6 7-Azaindole 
• 1006-94-6 5-methoxylindole 
• 98-59-9 p-toluenesulfonyl chloride 
• 192189-10-9 3-iodo-5-methoxyindole-1-carboxylic acid tert-butyl ester 

Downstream Products

• 348638-10-8 {5-methoxy-3-[1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-indol-1-yl}-acetic acid ethyl ester 
• 348639-01-0 2-(5-methoxy-1-methyl-1H-indol-3-yl)-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine 

Relevant articles and documents

Design of potent IGF1-R inhibitors related to bis-azaindoles

From an azaindole lead, identified in high throughput screen, a series of potent bis-azaindole inhibitors of IGF1-R have been synthesized using rational drug design and SAR based on a in silico binding mode hypothesis. Although the resulting compounds produced the expected improved potency, the model was not validated by the co-crystallization experiments with IGF1-R.