349536-41-0 Usage
Description
6'-DesMethyl-6'-Methylhydroxy Etoricoxib is a derivative of Etoricoxib, a selective cyclo-oxygenase-2 (COX-2) inhibitor. It is characterized by the absence of a methyl group at the 6' position and the presence of a methylhydroxy group at the same position. This modification may result in different pharmacological properties compared to the parent compound, Etoricoxib.
Uses
Used in Pharmaceutical Industry:
6'-DesMethyl-6'-Methylhydroxy Etoricoxib is used as an impurity in the production of Etoricoxib (E934100) for the treatment of osteoarthritis and rheumatoid arthritis. As a COX-2 inhibitor, it helps improve the signs and symptoms of these conditions by reducing inflammation and pain.
Possible additional uses (not provided in the materials, but can be inferred based on the properties of COX-2 inhibitors):
1. Used in Pain Management:
6'-DesMethyl-6'-Methylhydroxy Etoricoxib could be utilized as an analgesic agent for the management of various types of pain, including acute and chronic pain conditions, due to its COX-2 inhibitory properties.
2. Used in Anti-inflammatory Applications:
Given its COX-2 inhibitory activity, 6'-DesMethyl-6'-Methylhydroxy Etoricoxib may also be employed as an anti-inflammatory agent to alleviate inflammation in various conditions, such as tendinitis, bursitis, and other soft tissue injuries.
3. Used in Gastroprotective Applications:
COX-2 inhibitors, like 6'-DesMethyl-6'-Methylhydroxy Etoricoxib, may have potential applications in gastroprotection, as they can reduce the risk of gastrointestinal side effects associated with non-selective NSAIDs.
Check Digit Verification of cas no
The CAS Registry Mumber 349536-41-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,4,9,5,3 and 6 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 349536-41:
(8*3)+(7*4)+(6*9)+(5*5)+(4*3)+(3*6)+(2*4)+(1*1)=170
170 % 10 = 0
So 349536-41-0 is a valid CAS Registry Number.
349536-41-0Relevant articles and documents
In vitro metabolism considerations, including activity testing of metabolites, in the discovery and selection of the COX-2 inhibitor etoricoxib (MK-0663)
Chauret, Nathalie,Yergey, James A,Brideau, Christine,Friesen, Richard W,Mancini, Joseph,Riendeau, Denis,Silva, Jose,Styhler, Angela,Trimble, Laird A,Nicoll-Griffith, Deborah A
, p. 1059 - 1062 (2001)
Characterization of the metabolites of the COX-2 inhibitor etoricoxib (MK-0663 and L-791, 456) produced in vitro indicate formation of an N-oxide pyridine and hydroxymethyl pyridine that can further be glucuronidated or oxidized to an acid. Significant turnover is observed in human hepatocytes. Several CYPs are involved in the oxidative biotranformations and, from in vitro studies, etoricoxib is not a potent CYP3A4 inducer or inhibitor. Based on an in vitro whole blood assay, none of the metabolites of etoricoxib inhibits COX-1 or contributes significantly to the inhibition of COX-2.
