349553-73-7

Basic information

• Product Name: 6-AZIDO-HEXYLAMINE
• Synonyms: REF DUPL: 6-Azido-hexylamine;1-Hexanamine, 6-azido-;6-AZIDO-HEXYLAMINE;6-azidohexan-1-amine;6-Azidohexan-1-amine - A1949;6-Azido-1-hexanamine
• CAS NO: 349553-73-7
• Molecular Formula: C₆H₁₄N₄
• Molecular Weight: 142.2
• Mol File: 349553-73-7.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-AZIDO-HEXYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-AZIDO-HEXYLAMINE(349553-73-7)
• EPA Substance Registry System: 6-AZIDO-HEXYLAMINE(349553-73-7)

Safety Data

• Hazardous Substances Data: 349553-73-7(Hazardous Substances Data)

Usage

General Description

6-Azido-hexylamine is a chemical compound consisting of a six-carbon chain with an azide group attached to the end. It is commonly used in the development of azide-alkyne click chemistry, which is a powerful tool for the synthesis of complex molecules. 6-AZIDO-HEXYLAMINE can also be used in the modification of biomolecules, such as proteins and nucleic acids, for various research and diagnostic applications. Additionally, 6-azido-hexylamine is a potential precursor in the preparation of functionalized nanoparticles, polymers, and other materials with specific chemical properties. However, it is important to handle this chemical with care, as azides can be potentially explosive and toxic if mishandled.

Upstream product

• 13028-54-1 1,6-diazidohexane 
• 629-03-8 1 ,6-dibromohexane 
• 603-35-0 triphenylphosphine 
• 24566-79-8 2-(6-bromohexyl)isoindole-1,3-dione 
• 1074-82-4 potassium phtalimide 

Downstream Products

• 78618-06-1 monobenzyloxycarbonyl hexamethylenediamine hydrochloride 
• 960004-91-5 NH₂-Gly-L-(O-phosphotyrosine)-Ser-Gly-Asp-N-(6-azidohexyl)amide 
• 960005-14-5 NH₂-Gly-L-(O-phosphotyrosine)-Glu-Ser-Gly-N-(6-azidohexyl)amide 
• 960005-11-2 NH₂-Gly-L-(O-phosphotyrosine)-Cys-Ser-Ala-N-(6-azidohexyl)amide 
• 960005-06-5 NH₂-Gly-Trp-L-(O-phosphotyrosine)-Trp-Gln-N-(6-azidohexyl)amide 
• 960005-05-4 NH₂-Gly-L-(O-phosphotyrosine)-Arg-Arg-Gln-N-(6-azidohexyl)amide 
• 960004-66-4 NH₂-Pro-Tyr-L-(O-phosphotyrosine)-Tyr-Val-N-(6-azidohexyl)amide 
• 960005-08-7 NH₂-Pro-L-(O-phosphotyrosine)-Asp-Ile-Thr-N-(6-azidohexyl)amide 
• 960004-70-0 NH₂-Leu-Ser-L-(O-phosphotyrosine)-Arg-Gly-N-(6-azidohexyl)amide 
• 960005-03-2 NH₂-Leu-L-(O-phosphotyrosine)-Cys-Cys-Val-N-(6-azidohexyl)amide 
• 960004-73-3 NH₂-Leu-Ala-L-(O-phosphotyrosine)-Glu-Asp-N-(6-azidohexyl)amide 
• 960004-94-8 NH₂-Leu-L-(O-phosphotyrosine)-Glu-Asp-N-(6-azidohexyl)amide 
• 960004-62-0 NH₂-Leu-Cys-L-(O-phosphotyrosine)-Lys-Ala-N-(6-azidohexyl)amide 
• 960004-64-2 NH₂-Leu-Tyr-L-(O-phosphotyrosine)-Lys-Gln-N-(6-azidohexyl)amide 

Relevant articles and documents

Monosaccharides as Versatile Units for Water-Soluble Supramolecular Polymers

We introduce monosaccharides as versatile water-soluble units to compatibilise supramolecular polymers based on the benzene-1,3,5-tricarboxamide (BTA) moiety with water. A library of monosaccharide-based BTAs is evaluated, varying the length of the alkyl chain (hexyl, octyl, decyl and dodecyl) separating the BTA and saccharide units, as well as the saccharide units (α-glucose, β-glucose, α-mannose and α-galactose). In all cases, the monosaccharides impart excellent water compatibility. The length of the alkyl chain is the determining factor to obtain either long, one-dimensional supramolecular polymers (dodecyl spacer), small aggregates (decyl spacer) or molecularly dissolved (octyl and hexyl) BTAs in water. For the BTAs comprising a dodecyl spacer, our results suggest that a cooperative self-assembly process is operative and that the introduction of different monosaccharides does not significantly change the self- assembly behaviour. Finally, we investigate the potential of post-assembly functionalisation of the formed supramolecular polymers by taking advantage of dynamic covalent bond formation between the monosaccharides and benzoxaboroles. We observe that the supramolecular polymers readily react with a fluorescent benzoxaborole derivative permitting imaging of these dynamic complexes by confocal fluorescence microscopy.

Carrier-Free Delivery of Precise Drug–Chemogene Conjugates for Synergistic Treatment of Drug-Resistant Cancer

Combinatorial antitumor therapies using different combinations of drugs and genes are emerging as promising ways to overcome drug resistance, which is a major cause for the failure of cancer treatment. However, dramatic pharmacokinetic differences of drug

Structure-Based Design of 3-(4-Aryl-1H-1,2,3-triazol-1-yl)-Biphenyl Derivatives as P2Y14 Receptor Antagonists

UDP and UDP-glucose activate the P2Y14 receptor (P2Y14R) to modulate processes related to inflammation, diabetes, and asthma. A computational pipeline suggested alternatives to naphthalene of a previously reported P2Y14R antagonist (3, PPTN) using docking and molecular dynamics simulations on a hP2Y14R homology model based on P2Y12R structures. By reevaluating the binding of 3 to P2Y14R computationally, two alternatives, i.e., alkynyl and triazolyl derivatives, were identified. Improved synthesis of fluorescent antagonist 4 enabled affinity quantification (IC50s, nM) using flow cytometry of P2Y14R-expressing CHO cells. p-F3C-phenyl-triazole 65 (32) was more potent than a corresponding alkyne 11. Thus, additional triazolyl derivatives were prepared, as guided by docking simulations, with nonpolar aryl substituents favored. Although triazoles were less potent than 3 (6), simpler synthesis facilitated further structural optimization. Additionally, relative P2Y14R affinities agreed with predicted binding of alkynyl and triazole analogues. These triazoles, designed through a structure-based approach, can be assessed in disease models.