3517-90-6

Basic information

• Product Name: 4-METHOXYPHENYLMETHYLSULFONE
• Synonyms: 4-METHOXYPHENYLMETHYLSULFONE;1-METHANESULFONYL-4-METHOXY-BENZENE;4-methoxyphenyl methyl sulphone;NSC87355;1-(Methylsulfonyl)-4-methoxybenzene;1-Methoxy-4-(methylsulfonyl)benzene;1-Methoxy-4-methylsulfonylbenzene;4-Methoxy-1-(methylsulfonyl)benzene
• CAS NO: 3517-90-6
• Molecular Formula: C₈H₁₀O₃S
• Molecular Weight: 186.23
• Mol File: 3517-90-6.mol
• Article Data: 202

Chemical Properties

• Melting Point: 120-121.5°C
• Boiling Point: 341.1 °C at 760 mmHg
• Flash Point: 160.1 °C
• Appearance: /
• Density: 1.199 g/cm³
• Vapor Pressure: 0.000163mmHg at 25°C
• Refractive Index: 1.511
• Storage Temp.: Room temperature.
• CAS DataBase Reference: 4-METHOXYPHENYLMETHYLSULFONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHOXYPHENYLMETHYLSULFONE(3517-90-6)
• EPA Substance Registry System: 4-METHOXYPHENYLMETHYLSULFONE(3517-90-6)

Safety Data

• Hazardous Substances Data: 3517-90-6(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 28, p. 1945, 1963 DOI: 10.1021/jo01042a536

InChI:InChI=1/C8H10O3S/c1-11-7-3-5-8(6-4-7)12(2,9)10/h3-6H,1-2H3

Upstream product

• 1879-16-9 1-methoxy-4-methylsulfanyl-benzene 
• 3517-99-5 1-methoxy-4-(methylsulfinyl)benzene 
• 30541-56-1 adamantylidene-adamantane 
• 132102-78-4 diphenylmethyl <(p-methoxyphenyl)sulfonyl>methyl sulfoxide 
• 6462-31-3 methyl 2,4,6-trimethylphenyl sulfone 
• 100-66-3 methoxybenzene 
• 7143-01-3 Methanesulfonic anhydride 
• 6462-50-6 sodium 4-methoxybenzenesulfinate 
• 74-88-4 methyl iodide 
• 93-59-4 Perbenzoic acid 
• 22821-86-9 1,4-bis(methanesulfonyl)benzene 
• 696-62-8 para-iodoanisole 
• 20277-69-4 sodium methansulfinate 
• 104-92-7 1-bromo-4-methoxy-benzene 

Downstream Products

• 14763-60-1 4-methanesulfonyl-phenol 
• 132102-84-2 diphenylmethyl <(p-methoxyphenyl)sulfonyl>methyl sulfide 
• 1129-26-6 4-methoxybenzene sulfonamide 
• 71425-58-6 C₁₅H₁₆O₄S₂ 
• 58940-95-7 Aethoxy-oxalyl-methyl-p-methoxyphenyl-sulfon 
• 140-67-0 Estragole 
• 613-37-6 4-methoxylbiphenyl 
• 100-66-3 methoxybenzene 
• 132102-78-4 diphenylmethyl <(p-methoxyphenyl)sulfonyl>methyl sulfoxide 
• 885052-33-5 5-methanesulfonyl-2-methoxybenzenesulfonyl chloride 
• 1047974-45-7 (E)-1-(4-methoxyphenylsulfonyl)-4-phenylbut-3-en-2-ol 
• 14223-10-0 1-(benzylsulfonyl)-4-methoxybenzene 
• 203247-70-5 1-methoxy-4-(phenethylsulfonyl)benzene 
• 108545-54-6 1-methoxy-4-((4-methylbenzyl)sulfonyl)benzene 

Relevant articles and documents

High Chemoselectivity in the Construction of Aryl Methyl Sulfones via an Unexpected C-S Bond Formation between Sulfonylhydrazides and Dimethyl Phosphite

A highly chemoselective route to aryl methyl sulfones via an unexpected C S bond formation between sulfonylhydrazides and dimethyl phosphite catalyzed by NaI under mild conditions has been established. This transformation provides an alternative and metal-free pathway to acquire various aryl methyl sulfones in good to excellent yields. Notably, dimethyl phosphite was employed as a stable and readily available alkyl source.

Electrochemical oxygenation of sulfides with molecular oxygen or water: Switchable preparation of sulfoxides and sulfones

A practical and eco-friendly method for the controllable aerobic oxygenation of sulfides by electrochemical catalysis was developed. The switchable preparation of sulfoxides and sulfones was effectively controlled by reaction time, in which both molecular oxygen and water can be used as the oxygen source under catalyst and external oxidant-free conditions. The electrochemical protocol features a broad substrate scope and excellent site selectivity and is successfully applied to the modification of some sulfide-containing pharmaceuticals and their derivatives. This journal is

Electrochemical Scalable Sulfoxidation of Sulfides with Molecular Oxygen and Water

An efficient and chemoselective synthesis of sulfoxides through the electrooxidation of sulfides has been well developed. This protocol takes advantage of electricity as the terminal oxidant and of molecular oxygen and water as the oxygen atom sources. A variety of structurally diverse sulfoxide compounds are assembled in moderate to excellent yields. The scaled-up reactions at 6–20 mmol show the good practicability and application potential of this methodology. A possible free radical mechanism has been proposed to rationalize the reaction procedure.