14763-60-1 Usage
Description
4-Methylsulfonylphenol, also known as 4-(Methylsulfonyl)phenol, is an organic compound with the chemical formula C7H8O3S. It is a tan to pink-brown powder and is used as a reagent in the synthesis of various chemical compounds.
Uses
Used in Pharmaceutical Industry:
4-Methylsulfonylphenol is used as a reagent for the synthesis of pyrazolo[3,4-d]pyrimidine derivatives, which are known as GPR119 agonists. These agonists have potential applications in the treatment of type 2 diabetes and obesity by modulating glucose homeostasis and insulin secretion.
Additionally, 4-Methylsulfonylphenol is used as a reagent in the synthesis of novel 2-(pyridine-2-yl)-1H-benzimidazole derivatives. These derivatives act as potent glucokinase activators, which can be utilized in the development of therapies for type 2 diabetes by improving glucose metabolism and insulin sensitivity.
Reactions
The reaction of 4-(methylsulfonyl)phenol (17.2 g, 100.0 mmol) with p-Toluenesulfonic anhydride as outlined in the general procedure provided 4-(methylsulfonyl)phenyl 4-methylbenzenesulfonate (26.1 g, 81%).
Check Digit Verification of cas no
The CAS Registry Mumber 14763-60-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,7,6 and 3 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 14763-60:
(7*1)+(6*4)+(5*7)+(4*6)+(3*3)+(2*6)+(1*0)=111
111 % 10 = 1
So 14763-60-1 is a valid CAS Registry Number.
InChI:InChI=1/C9H13NO2/c10-6-8(11)7-12-9-4-2-1-3-5-9/h1-5,8,11H,6-7,10H2
14763-60-1Relevant articles and documents
A general copper-catalyzed sulfonylation of arylboronic acids
Kar, Anirban,Sayyed, Lliyas Ali,Lo, Wei Fun,Kaiser, Hanns Martin,Beller, Matthias,Tse, Man Kin
, p. 3405 - 3408 (2007)
A general copper-catalyzed method for the sulfonylation of arylboronic acids with sulfinate salts is described. A variety of alkyl-aryl, diaryl, and alkyl-heteroaryl sulfones were synthesized in good yield.
COMPOSITES, METHODS AND USES THEREOF
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Page/Page column 22-23, (2021/06/04)
The present invention relates, in general terms, to methods of catalysing a reaction, including the steps of contacting a chemical entity comprising a sulphide moiety with a composite and an oxidant. The composite acts as a heterogeneous catalyst to oxidise the sulphide moiety. The present invention also relates to composites, methods of synthesising the composites and its use as a catalyst thereof.
Modulation of photochemical oxidation of thioethers to sulfoxides or sulfones using an aromatic ketone as the photocatalyst
Zhao, Bin,Hammond, Gerald B.,Xu, Bo
supporting information, (2021/09/13)
We have developed an eco-friendly and chemo-selective photocatalytic synthesis of sulfoxides or sulfones via oxidation of sulfides (thioethers) at ambient temperature using air or O2 as the oxidant. An inexpensive thioxanthone was used as the photocatalyst. Our method offers excellent chemical yields and good functional group tolerance. The hydrogen bonding between hexafluoro-2-propanol (HFIP) and sulfoxides may play an important role in minimizing the over-oxidization of sulfoxides.
