99186-51-3

Basic information

• Product Name: 1-(allyloxy)-4-(methylsulfonyl)benzene
• Synonyms: 1-(allyloxy)-4-(methylsulfonyl)benzene
• CAS NO: 99186-51-3
• Molecular Weight: 212.269
• Mol File: 99186-51-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(allyloxy)-4-(methylsulfonyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(allyloxy)-4-(methylsulfonyl)benzene(99186-51-3)
• EPA Substance Registry System: 1-(allyloxy)-4-(methylsulfonyl)benzene(99186-51-3)

Safety Data

• Hazardous Substances Data: 99186-51-3(Hazardous Substances Data)

Upstream product

• 14763-60-1 4-methanesulfonyl-phenol 
• 106-95-6 allyl bromide 
• 73441-60-8 (4-(allyloxy)phenyl)(methyl)sulfane 
• 637-89-8 4-sulfanylphenol 
• 1073-72-9 4-hydroxythioanisole 

Downstream Products

• 99186-54-6 2-allyl-4-methanesulfonyl-phenol 

Relevant articles and documents

Enantioselective Synthesis of 3-Fluorochromanes via Iodine(I)/Iodine(III) Catalysis

The chromane nucleus is common to a plenum of bioactive small molecules where it is frequently oxidized at position 3. Motivated by the importance of this position in conferring efficacy, and the prominence of bioisosterism in drug discovery, an iodine(I)/iodine(III) catalysis strategy to access enantioenriched 3-fluorochromanes is disclosed (up to 7:93 e.r.). In situ generation of ArIF2 enables the direct fluorocyclization of allyl phenyl ethers to generate novel scaffolds that manifest the stereoelectronic gauche effect. Mechanistic interrogation using deuterated probes confirms a stereospecific process consistent with a type IIinv pathway.