352-03-4

Basic information

• Product Name: 3-(4-FLUORO-PHENYL)-ACRYLIC ACID ETHYL ESTER
• Synonyms: 4'-FLUOROCINNAMIC ACID ETHYL ESTER;3-(4-FLUORO-PHENYL)-ACRYLIC ACID ETHYL ESTER;ETHYL 4-FLUOROCINNAMATE;ethyl (2E)-3-(4-fluorophenyl)acrylate;(E)-3-(4-Fluorophenyl)acrylic acid ethyl ester;4-Fluoro-trans-cinnamic acid ethyl ester
• CAS NO: 352-03-4
• Molecular Formula: C₁₁H₁₁FO₂
• Molecular Weight: 194.2
• Product Categories: Aromatic Esters;pharmacetical;Miscellaneous
• Mol File: 352-03-4.mol
• Article Data: 124

Chemical Properties

• Melting Point: 30-32 °C
• Boiling Point: 131°C/5mmHg(lit.)
• Flash Point: 113°C
• Appearance: /
• Density: 1.134g/cm³
• Vapor Pressure: 0.00744mmHg at 25°C
• Refractive Index: 1.533
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-(4-FLUORO-PHENYL)-ACRYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-FLUORO-PHENYL)-ACRYLIC ACID ETHYL ESTER(352-03-4)
• EPA Substance Registry System: 3-(4-FLUORO-PHENYL)-ACRYLIC ACID ETHYL ESTER(352-03-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 352-03-4(Hazardous Substances Data)

Usage

General Description

3-(4-fluoro-phenyl)-acrylic acid ethyl ester is a chemical compound with the molecular formula C11H11FO2. It is an ester derivative of acrylic acid, containing a 4-fluoro-phenyl group. 3-(4-FLUORO-PHENYL)-ACRYLIC ACID ETHYL ESTER is used in the production of pharmaceuticals and as a building block in organic synthesis. It is also used in the manufacturing of polymers and resins. The presence of the 4-fluoro-phenyl group makes this compound potentially useful in the development of new drugs and materials. Additionally, it may have applications in the field of organic electronics and optoelectronics.

InChI:InChI=1/C11H11FO2/c1-2-14-11(13)8-5-9-3-6-10(12)7-4-9/h3-8H,2H2,1H3/b8-5+

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 105-36-2 ethyl bromoacetate 
• 459-32-5 4-fluorocinnamic acid 
• 64-17-5 ethanol 
• 140-88-5 ethyl acrylate 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 133505-33-6 carbethoxymethyldibutyltelluronium bromide 
• 38788-38-4 dibutyl telluride 
• 141-78-6 ethyl acetate 
• 74929-23-0 3-(4-fluorophenyl)-2-propynal 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 108269-39-2 ethyl 2-(diethoxyphosphoryl)acetate potassium salt 
• 352-34-1 4-fluoro-1-iodobenzene 

Downstream Products

• 459-32-5 (E)-4-fluorocinnamic acid 
• 7116-38-3 ethyl 3-(4-fluorophenyl)propanoate 
• 412274-07-8 trans-ethyl 3-(4-fluorophenyl)oxirane-2-carboxylate 
• 42122-47-4 2,3-dibromo-3-(4-fluoro-phenyl)-propionic acid ethyl ester 
• 191668-10-7 ethyl 4-(4-fluorophenyl)-1H-pyrrole-3-carboxylate 
• 124980-95-6 (E)-3-(4-fluorophenyl)-2-propen-1-ol 
• 911301-34-3 ethyl 2-azido-3-(4-fluorophenyl)acrylate 
• 24484-55-7 1-bromo-3-(4-fluorophenyl)propane 
• 702-15-8 3-(4-fluorophenyl)propan-1-ol 
• 917247-89-3 rac-2-hydroxy-4-(4-fluorophenyl)butanoic acid 
• 114990-93-1 (R)-2-hydroxy-4-(4-fluorophenyl)butanoic acid 
• 225233-79-4 rac-2-amino-4-(4-fluorophenyl)butanoic acid 
• 63416-70-6 3-(4-fluorophenyl)propanal 

Relevant articles and documents

Identification of (6S)-cyclopropyl-6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxamines as new HBV capsid assembly modulators

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Synthesis method of selenium-containing isochroman compound

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Hypervalent iodine(iii) induced oxidative olefination of benzylamines using Wittig reagents

We have developed hypervalent iodine(iii) induced oxidative olefination of primary and secondary benzylamines using 2C-Wittig reagents, which provides easy access to α,β-unsaturated esters. Mild reaction conditions, good to excellent yields with high (E) selectivity, and a broad substrate scope are the key features of this reaction. We have successfully carried out the gram-scale synthesis of α,β-unsaturated esters.