35564-99-9Relevant articles and documents
A solid- and solution-phase-based library of 2β-methyl substituted penicillin derivatives and their effects on growth inhibition of tumor cell lines
Boggián, Dora B.,Cornier, Patricia G.,Mata, Ernesto G.,Blank, Viviana C.,Cárdenas, Mariano G.,Roguin, Leonor P.
, p. 619 - 625 (2015)
We described the design, synthesis and antiproliferative properties of a series of twenty 2β-methyl substituted penicillin derivatives. This analysis includes evaluation against HeLa and MCF-7 human tumor cell lines and LM3 and B16-F0 murine tumor cell lines. The epithelial cell line derived from the normal mammary gland of mice (NMuMG) and the mouse embryo fibroblast cell line (3T3) were used as controls (non-cancer cells). This journal is
Butylstannonic acid catalyzed transesterification of carboxylic esters
Furlan, Ricardo L. E.,Mata, Ernesto G.,Mascaretti, Oreste A.
, p. 2257 - 2260 (2007/10/03)
Butylstannonic acid is used as catalyst for transesterification of various carboxylic eaters. This method is also applicable to acetylation/deacetylation of alcohols.
Carbapenams and carbapen-2-ems and process therefor
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, (2008/06/13)
Carbapenam-3-carboxylic acids and carbapen-2-em-3-carboxylic acids substituted at the 1-position with an oxo, a hydroxy or an acetoxy group, variously substituted at the 2-position with such groups as methyl, acetoxymethyl, methanesulfonyloxy, alkoxy, alkylthio, aminoalkylthio or amidinoalkylthio and optionally substituted at the 6-position with a hydroxyalkyl group, an acetoxyalkyl group or a conventional penicillin side-chain, pharmaceutically-acceptable salts thereof and various esters thereof wherein the esterifying group is selectively removed in the laboratory, or hydrolyzed under physiological conditions. These compounds are useful either systemically or topically in the treatment of diseases caused by susceptible microorganisms, as animal feed additives for promotion of growth, or in the preservation of biodegradable materials, or as intermediates to compounds having such antibacterial activity. Key to the synthesis of these compounds is the light catalyzed rearrangement of 2-diazo-1-oxoceph-3-em-4-carboxylates to 1-oxocarbapen-2-em-3-carboxylates, a newly discovered reaction determined to be of general applicability.
