359700-09-7

Basic information

• Product Name: 1H-Indole-1-carboxylic acid, 3-[(1E)-2-carboxyethenyl]-, 1-(1,1-dimethylethyl) ester
• CAS NO: 359700-09-7
• Molecular Formula: C16H17NO4
• Molecular Weight: 287.315
• Mol File: 359700-09-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1H-Indole-1-carboxylic acid, 3-[(1E)-2-carboxyethenyl]-, 1-(1,1-dimethylethyl) ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-1-carboxylic acid, 3-[(1E)-2-carboxyethenyl]-, 1-(1,1-dimethylethyl) ester(359700-09-7)
• EPA Substance Registry System: 1H-Indole-1-carboxylic acid, 3-[(1E)-2-carboxyethenyl]-, 1-(1,1-dimethylethyl) ester(359700-09-7)

Safety Data

• Hazardous Substances Data: 359700-09-7(Hazardous Substances Data)

Upstream product

• 388631-93-4 (E)-tert-butyl 3-(3-methoxy-3-oxoprop-1-en-1-yl)-1H-indole-1-carboxylate 
• 19626-92-7 trans-3-(3-indolyl)acrylsaeuremethylester 
• 1204-06-4 trans-3-indole-acrylic acid 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 876307-10-7 tert-butyl 3-((1E)-3-oxo-3-((4R)-2-oxo-phenyloxazolidin-3-yl)prop-1-en-1-yl)-1H-indole-1-carboxylate 
• 1569645-11-9 (E)-tert-butyl 3-(3-(2-(4-fluorobenzoyl)-1-isopropylhydrazinyl)-3-oxoprop-1-enyl)-1H-indole-1-carboxylate 
• 1407499-53-9 (E)-tert-butyl 3-(3-(2-(3-fluorobenzoyl)-1-isopropylhydrazinyl)-3-oxoprop-1-enyl)-1H-indole-1-carboxylate 
• 1407499-58-4 (E)-tert-butyl 3-(3-(2-(3-(2-amino-2-oxoethoxy)benzoyl)-1-isopropylhydrazinyl)-3-oxoprop-1-enyl)-1H-indole-1-carboxylate 
• 1407499-73-3 (E)-tert-butyl 3-(3-(2-(4-(2-bromoethoxy)benzoyl)-1-isopropylhydrazinyl)-3-oxoprop-1-enyl)-1H-indole-1-carboxylate 
• 1407499-72-2 (E)-tert-butyl 3-(3-(2-(3-(2-bromoethoxy)benzoyl)-1-isopropylhydrazinyl)-3-oxoprop-1-enyl)-1H-indole-1-carboxylate 
• 1407499-39-1 (E)-tert-butyl 3-(3-(2-benzoyl-1-isopropylhydrazinyl)-3-oxoprop-1-enyl)-1H-indole-1-carboxylate 
• 1407499-54-0 (E)-tert-butyl 3-(3-(2-benzoylhydrazinyl)-3-oxoprop-1-enyl)-1H-indole-1-carboxylate 
• 1407499-52-8 (E)-tert-butyl 3-(3-(2-(4-chlorobenzoyl)-1-isopropylhydrazinyl)-3-oxoprop-1-enyl)-1H-indole-1-carboxylate 
• 1407499-51-7 (E)-tert-butyl 3-(3-(2-(4-bromobenzoyl)-1-isopropylhydrazinyl)-3-oxoprop-1-enyl)-1H-indole-1-carboxylate 
• 1407499-50-6 (E)-tert-butyl 3-(3-(2-(3-bromobenzoyl)-1-isopropylhydrazinyl)-3-oxoprop-1-enyl)-1H-indole-1-carboxylate 
• 1407499-57-3 (E)-2-(3-(2-(3-(1-(tert-butoxycarbonyl)-1H-indol-3-yl)acryloyl)-2-isopropylhydrazinecarbonyl)phenoxy)acetic acid 
• 1407499-56-2 (E)-tert-butyl 3-(3-(1-isopropyl-2-(3-(2-methoxy-2-oxoethoxy)benzoyl)hydrazinyl)-3-oxoprop-1-enyl)-1H-indole-1-carboxylate 
• 1407499-49-3 (E)-tert-butyl 3-(3-(1-isopropyl-2-(4-(2-methoxyethoxy)benzoyl)hydrazinyl)-3-oxoprop-1-enyl)-1H-indole-1-carboxylate 

Relevant articles and documents

MULTIBIOTIC AGENTS AND METHODS OF USING THE SAME

Multibiotic agents are disclosed. The multibiotic agents may contain two or more moieties linked through bonds cleavable in vivo. The bonds cleavable in vivo can be ester bonds, amide bonds, azo bonds, glycosidic bonds, carbonate linkers, or carbamate linkers. The moieties can be alcohol cores, amine cores, and/or acyls. Also disclosed are compositions containing multibiotic agents and methods of using the multibiotic agents.

Discovery of a novel series of indolyl hydrazide derivatives as diacylglycerol acyltransferase-1 inhibitors

A novel series of hydrazide derivatives were synthesized as potential diacylglycerol acyltransferase (DGAT) inhibitors. Among them, compounds 8u and 8v exhibited selective and potent DGAT-1 inhibitory activities. In addition, compound 8u dose-dependently inhibited triglyceride synthesis in HepG2 cell lines. Furthermore, treatment with compound 8u for an oral lipid tolerance test showed a significant decrease in plasma triglyceride levels compared with vehicle-treated control animals, indicating delayed absorption of triglyceride after an acute lipid challenge.