362609-92-5

Basic information

• Product Name: 3,4-(METHYLENEDIOXY)PHENYLGLYOXAL HYDRATE
• Synonyms: BENZO[D][1,3]DIOXOLE-5-GLYOXAL HYDRATE;3,4-(METHYLENEDIOXY)PHENYLGLYOXAL HYDRATE;3,4-METHYLENEDIOXYPHENYLGLYOXAL HYDRATE, 95+%;2-(Benzo[d][1,3]dioxol-5-yl)-2-oxoacetaldehyde hydrate
• CAS NO: 362609-92-5
• Molecular Formula: C₉H₈O₅
• Molecular Weight: 196.16
• Mol File: 362609-92-5.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 3,4-(METHYLENEDIOXY)PHENYLGLYOXAL HYDRATE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-(METHYLENEDIOXY)PHENYLGLYOXAL HYDRATE(362609-92-5)
• EPA Substance Registry System: 3,4-(METHYLENEDIOXY)PHENYLGLYOXAL HYDRATE(362609-92-5)

Safety Data

• Hazardous Substances Data: 362609-92-5(Hazardous Substances Data)

Usage

General Description

3,4-(Methylenedioxy)phenylglyoxal hydrate, also known as Safrole glyoxal, is a chemical compound with the molecular formula C10H10O4. It is a colorless to pale yellow crystalline solid that is soluble in water and organic solvents. 3,4-(METHYLENEDIOXY)PHENYLGLYOXAL HYDRATE is commonly used in the organic synthesis of various pharmaceutical and agricultural products. It is also used as an intermediate in the synthesis of fragrances and flavoring compounds. Additionally, 3,4-(Methylenedioxy)phenylglyoxal hydrate has been studied for its potential antimicrobial and antifungal properties, making it an important chemical in the field of biomedical research.

Upstream product

• 3162-29-6 1-(benzo[d][1,3]dioxol-6-yl)ethanone 
• 65709-23-1 3,4-methylenedioxyphenylglyoxal 

Downstream Products

• 1353896-78-2 2-(benzo[d][1,3]dioxol-5-yl)-1-(4-bromophenyl)-4,5,6,7-tetrahydro-6,6-dimethyl-4-oxo-1H-indol-7-yl acetate 
• 1353896-79-3 2-(benzo[d][1,3]dioxol-5-yl)-1-(4-bromophenyl)-4,5,6,7-tetrahydro-6,6-dimethyl-4-oxo-1H-indol-7-yl propionate 
• 1353896-81-7 2-(benzo[d][1,3]dioxol-5-yl)-1-(4-bromophenyl)-4,5,6,7-tetrahydro-6,6-dimethyl-4-oxo-1H-indol-7-yl isobutyrate 
• 1353896-80-6 2-(benzo[d][1,3]dioxol-5-yl)-1-(4-bromophenyl)-4,5,6,7-tetrahydro-6,6-dimethyl-4-oxo-1H-indol-7-yl butyrate 
• 1353896-90-8 2-(benzo[d][1,3]dioxol-5-yl)-7-(2-benzo[d][1,3]dioxol-6-yl)-1-(4-chlorophenyl-4-hydroxy-1H-indol-3-yl)-1-(4-chlorophenyl)-6,7-dihydro-1H-indol-4(5H)-one 
• 1353896-92-0 2-(benzo[d][1,3]dioxol-5-yl)-7-(2-(benzo[d][1,3]dioxol-6-yl)-1-(4-fluorophenyl)-4-hydroxy-1H-indol-3-yl)-1-(4-fluorophenyl)-6,7-dihydro-1H-indol-4(5H)-one 
• 31197-66-7 isopropyl benzoylformate 
• 53439-96-6 (S)-α-hydroxyphenylacetic acid iso-propyl ester 
• 89015-27-0 (R)-α-hydroxyphenylacetic acid iso-propyl ester 

Relevant articles and documents

Novel and convenient one-pot strategy for regioselective synthesis of new 5-aryl-3-methyl-1-phenyl-1,2-dihydro-7aH-pyrazolo[3,4-c]pyridazin-7a-ol derivatives

Abstract: We describe a novel and simple regioselective synthesis of 5-aryl-3-methyl-1-phenyl-1,2-dihydro-7aH-pyrazolo[3,4-c]pyridazin-7a-ol derivatives via one-pot three-component reaction of arylglyoxalmonohydrates, 5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and hydrazine hydrate in presence of 1,4-diazabicyclo[2.2.2]octane (DABCO) as base-organocatalyst at room temperature in acetonitrile. This one-pot method has the advantages of simple methodology, high atom economy, cost-effectiveness, high regioselectivity, and easy workup. Graphical Abstract: [Figure not available: see fulltext.].

A Green and Convenient Route for the Regioselective Synthesis of New Substituted 3-Aryl-5H-indeno[1,2-c]pyridazines as Potential Monoamine Oxidase Type A Inhibitors

Several indeno[1,2-c]pyridazines were efficiently synthesised using the one-pot, three-component reaction of substituted indanones, arylglyoxalmonohydrates, and hydrazine in the presence of 1,5-diazabicyclo[4,3,0]non-5-ene (DBN) in water at room temperature. These substituted 3-aryl indeno[1,2-c]pyridazines can be considered as potential monoamine oxidase type A (MAOA) inhibitors. The advantages of this new strategy are the novelty of the indenopyridazine derivatives, high regioselectivity, use of water as the solvent, no requirement for toxic metal catalysts, and good to excellent yields.

Nucleophilic addition of (difluoromethyl)trimethylsilane to selected α-imino ketones and aryl diketones

Abstract Chemoselective addition of (difluoromethyl)trimethylsilane (CHF2SiMe3) to the carbonyl bond of aryl glyoxal derived α-imino ketones, and selected diaryl 1,2-diketones were studied in the presence of initiators, such as potas