36372-77-7

Basic information

• Product Name: 1,4,5-TRIPHENYL-1H-PYRAZOLE
• Synonyms: 1,4,5-TRIPHENYL-1H-PYRAZOLE
• CAS NO: 36372-77-7
• Molecular Formula: C₂₁H₁₆N₂
• Molecular Weight: 296.37
• Product Categories: pharmacetical
• Mol File: 36372-77-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 443 °C at 760 mmHg
• Flash Point: 221.7 °C
• Appearance: /
• Density: 1.08 g/cm³
• Vapor Pressure: 1.25E-07mmHg at 25°C
• Refractive Index: 1.624
• CAS DataBase Reference: 1,4,5-TRIPHENYL-1H-PYRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4,5-TRIPHENYL-1H-PYRAZOLE(36372-77-7)
• EPA Substance Registry System: 1,4,5-TRIPHENYL-1H-PYRAZOLE(36372-77-7)

Safety Data

• Hazardous Substances Data: 36372-77-7(Hazardous Substances Data)

Usage

Type of compound

Heterocyclic compound

Structure

Contains a pyrazole ring and three phenyl groups attached at different positions

Medicinal chemistry

Synthesis of various pharmaceuticals and bioactive compounds

Coordination chemistry

Used as a ligand

Material development

Potential applications in organic electronics and optoelectronics

Biological activities

a. Antimicrobial properties
b. Antifungal properties

InChI:InChI=1/C21H16N2/c1-4-10-17(11-5-1)20-16-22-23(19-14-8-3-9-15-19)21(20)18-12-6-2-7-13-18/h1-16H

Upstream product

• 451-40-1 phenyl benzyl ketone 
• 50-00-0 formaldehyd 
• 854699-69-7 1,4,5-triphenyl-1H-pyrazole-3-carboxylic acid 
• 41841-06-9 3,3-dimethoxy-1,2-diphenylpropan-1-one 
• 64-19-7 acetic acid 
• 100-63-0 phenylhydrazine 
• 5435-97-2 1-phenyl-1,2-dibenzoylethylene 
• 22563-99-1 3-dimethylamino-1,2-diphenyl-propan-1-one 
• 5669-11-4 3-oxo-2,3-diphenylpropanal 
• 54925-91-6 1,2-Diphenyl-3-phenylaminopropen-1-one 
• 64-17-5 ethanol 
• 13249-75-7 (Z)-1,2,4-triphenyl-2-butene-1,4-dione 
• 309297-08-3 4,5-bis(2-bromophenyl)-1-phenylpyrazole 
• 309297-09-4 4,5-bis(2-iodophenyl)-1-phenylpyrazole 

Downstream Products

• 65480-21-9 1-Phenylphenanthro[9,10-d]pyrazole 
• 7189-13-1 1,3,4,5-tetraphenyl-1H-pyrazole 

Relevant articles and documents

Regioselective rapid analog synthesis of 1,3-(or 1,5-)diphenyl-4-aryl/ heteroaryl-5-(or 3-)(methylthio)pyrazoles via Suzuki cross-coupling

Regioselective routes for the synthesis of 1,3-(or 1,5-)diphenyl-4-aryl/ heteroaryl-5-(or 3-)(methylthio)pyrazoles via Suzuki cross-coupling of 4-bromo (or 4-iodo)-1,3-(or 1,5-)diphenyl-5-(or 3-)(methylthio)pyrazoles have been reported.

The chemistry of α,β-ditosyloxyketones: new and convenient route for the synthesis of 1,4,5-trisubstituted pyrazoles from α,β-chalcone ditosylates

The reaction of α,β-chalcone ditosylates with various reagents such as phenylhydrazine hydrochloride, semicarbazide hydrochloride and thiosemicarbazide in suitable conditions leads to 1,2-aryl shift, thereby providing a novel route for the synthesis of 1,4,5-trisubstituted pyrazoles.

A Combination of Tandem Amine-Exchange/Heterocyclization and Biaryl Coupling Reactions for the Straightforward Preparation of Phenanthro[9,10-d]pyrazoles

The tandem amine-exchange/heterocyclization of enaminoketones is successfully applied to the regioselective preparation of a series of new 4,5-diarylpyrazoles by reaction of phenylhydrazine and several 3-N,N-(dimethylamino)-1,2-diarylpropenones. The comparison of a vast array of biaryl coupling procedures provides general, complementary approaches to new phenanthro[9,10-d]-pyrazoles. The most efficient procedures for this final step in the construction of the tetracyclic system are based on a Stille-type tandem stannylation - biaryl coupling of o,o′-dihalogenated diarylpyrazoles and an hypervalent iodine-mediated nonphenolic oxidative coupling of nonhalogenated precursors.