5669-11-4

Basic information

• Product Name: 2-(2-oxo-2-phenylethyl)benzaldehyde
• Synonyms: 2-Formylbenzyl phenyl ketone
• CAS NO: 5669-11-4
• Molecular Formula: C₁₅H₁₂O₂
• Molecular Weight: 224.2546
• Mol File: 5669-11-4.mol
• Article Data: 9

Chemical Properties

• Melting Point: 112 °C(Solv: acetone (67-64-1); water (7732-18-5))
• Boiling Point: 381.3°C at 760 mmHg
• Flash Point: 143°C
• Density: 1.159g/cm³
• Vapor Pressure: 5.13E-06mmHg at 25°C
• Refractive Index: 1.615
• PKA: 4.94±0.29(Predicted)
• CAS DataBase Reference: 2-(2-oxo-2-phenylethyl)benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-oxo-2-phenylethyl)benzaldehyde(5669-11-4)
• EPA Substance Registry System: 2-(2-oxo-2-phenylethyl)benzaldehyde(5669-11-4)

Safety Data

• Hazardous Substances Data: 5669-11-4(Hazardous Substances Data)

Upstream product

• 451-40-1 phenyl benzyl ketone 
• 109-94-4 formic acid ethyl ester 
• 7570-85-6 trans-2,3-epoxy-1,3-diphenyl-1-propanone 
• 60-29-7 diethyl ether 
• 109-63-7 trifluoroborane diethyl ether 
• 5411-12-1 chalcone epoxide 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 1817-49-8 1,3-diphenyl-1-propyn-3-ol 
• 100-52-7 benzaldehyde 
• 98-86-2 acetophenone 
• 94-41-7 benzalacetophenone 

Downstream Products

• 6630-86-0 benzil phenylhydrazone 
• 36372-77-7 1,4,5-triphenyl-1H-pyrazole 
• 116376-07-9 1,2-diphenyl-3-(tert-butylimino)-2-propen-1-one 
• 2983-71-3 3-chloro-1,2-diphenyl-2-propen-1-one 
• 97015-47-9 N-(3-oxo-2,3-diphenyl-propenyl)-benzamide 
• 93331-57-8 N-Methyl-N'-<2-phenyl-2-benzoyl-vinyl>harnstoff 
• 54925-91-6 1,2-Diphenyl-3-phenylaminopropen-1-one 
• 58753-74-5 1,2-Diphenyl-3-benzylamino-Δ(2)-propen-on-(1) 
• 4702-72-1 benzil mono(p-nitrophenylhydrazone) 
• 451-40-1 phenyl benzyl ketone 
• 112175-88-9 N-tert-butyl-2,3-diphenyl-3-oxopropanamide 
• 3119-30-0 2-(2-Dimethylamino-ethoxy)-1-benzoyl-1-phenyl-ethylen 
• 3119-28-6 2-(2-Diethylamino-ethoxy)-1-benzoyl-1-phenyl-ethylen 
• 3119-26-4 2-(2-Diethylamino-ethylmercapto)-1-benzoyl-1-phenyl-ethylen 

Relevant articles and documents

A high-yielding protocol for the synthesis of 4,5-diarylpyrimidin-2-amine derivatives from chalcones

A novel, high yielding and versatile protocol was achieved for the synthesis of 4,5-diaryl-2-pyrimidinamine derivatives from chalcones. The synthesis was accomplished by converting the chalcones into 3-chloro-2,3-diaryl-2-propen-1-ones followed by subsequent reaction with amidine derivatives.

Practical approach for preparation of unsymmetric benzils from β-ketoaldehydes

An efficient and practical method for the synthesis of unsymmetric benzils from readily available β-ketoaldehydes has been developed. Various unsymmetric 1,2-diaryldiketones bearing functional groups have been obtained in good to excellent yields under mild reaction conditions. A plausible mechanism was proposed, and α,α-dichloroketone was considered as the key intermediate. The generation of α,α-dichloroketones from β-ketoaldehydes may undergo the following steps: (1) oxidation by sodium hypochlorite, (2) decarboxylation, and (3) chlorination by Cl2 generated from sodium hypochlorite.

PYRAZOLYL SUBSTITUTED CARBONIC ACID DERIVATIVES AS MODULATORS OF THE PROSTACYCLIN(PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO

Pyrazole derivatives of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pulmonary arterial hypertension (PAH) and related disorders; platelet aggregation; coronary artery disease; myocardial infarction; transient ischemic attack; angina; stroke; ischemia-reperfusion injury; restenosis; atrial fibrillation; blood clot formation in an angioplasty or coronary bypass surgery individual or in an individual suffering from atrial fibrillation; atherosclerosis; atherothrombosis; asthma or a symptom thereof; a diabetic-related disorder such as diabetic peripheral neuropathy, diabetic nephropathy or diabetic retinopathy; glaucoma or other disease of the eye with abnormal intraocular pressure; hypertension; inflammation; psoriasis; psoriatic arthritis; rheumatoid arthritis; Crohn's disease; transplant rejection; multiple sclerosis; systemic lupus erythematosus (SLE); ulcerative colitis; ischemia-reperfusion injury; restenosis; atherosclerosis; acne; type 1 diabetes; type 2 diabetes; sepsis; and chronic obstructive pulmonary disorder (COPD).