36772-63-1

Basic information

• Product Name: 7-chloro-1,2,3-benzotriazin-4(1H)-one
• CAS NO: 36772-63-1
• Molecular Formula: C₇H₄ClN₃O
• Molecular Weight: 181.5792
• Mol File: 36772-63-1.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 311.8°C at 760 mmHg
• Flash Point: 142.4°C
• Density: 1.66g/cm³
• Vapor Pressure: 0.000552mmHg at 25°C
• Refractive Index: 1.749
• CAS DataBase Reference: 7-chloro-1,2,3-benzotriazin-4(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-chloro-1,2,3-benzotriazin-4(1H)-one(36772-63-1)
• EPA Substance Registry System: 7-chloro-1,2,3-benzotriazin-4(1H)-one(36772-63-1)

Safety Data

• Hazardous Substances Data: 36772-63-1(Hazardous Substances Data)

Upstream product

• 40928-13-0 4-chloroisatoic anhydride 
• 5900-59-4 2-amino-4-chlorobenzamide 
• 89-77-0 2-Amino-4-chlorobenzoic acid 

Downstream Products

• 41994-99-4 2-(2-amino-4-chloro-phenyl)-7-chloro-benzo[d][1,3]oxazin-4-one 
• 91532-38-6 7-Chloro-3-{3-[4-(3-chloro-phenyl)-piperazin-1-yl]-propyl}-3H-benzo[d][1,2,3]triazin-4-one 

Relevant articles and documents

Synthesis of 1,2,3-benzotriazin-4-one derivatives containing spirocyclic indoline-2-one moieties and their nematicidal evaluation

To discover new chemotypes of nematicides with proper toxicological profiles, a series of novel 1,2,3-benzotriazin-4-one derivatives were synthesized and further bioevaluated. The bioassay results showed that most of the synthesized compounds were endowed with moderate to good control efficacy against Meloidogyne incognita at 10.0 mg/L in vivo. Among them, compounds 6k and 6p displayed 100% inhibitory activities at this concentration, which implied that they could be used as lead compounds for promising nematicides.

Synthesis and nematicidal activities of 1,2,3-benzotriazin-4-one containing 4,5-dihydrothiazole-2-thiol derivatives against Meloidogyne incognita

A series of novel 1,2,3-benzotriazin-4-one derivatives containing 4,5-dihydrothiazole-2-thiol were synthesized and characterized by 1H NMR, 13C NMR, 19F NMR and HRMS. The bioassay results showed that compounds 3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)-7-methoxybenzo[d][1–3]triazin-4(3H)-one, 3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)-6-nitrobenzo[d][1–3]triazin-4(3H)-one, 7-chloro-3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)benzo[d][1–3]triazin-4(3H)-one exhibited good control efficacy against the cucumber root-knot nematode disease caused by Meloidogyne incognita at the concentration of 10.0 mg L?1 in vivo. Compound 7-chloro-3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)benzo[d][1–3]triazin-4(3H)-one showed excellent nematicidal activity with inhibition 68.3% at a concentration of 1.0 mg L?1. It suggested that the structure of 1,2,3-benzotriazin-4-one containing 4,5-dihydro-thiazole-2-thiol could be optimized further.

Synthesis and nematicidal evaluation of 1,2,3-benzotriazin-4-one derivatives containing piperazine as linker against Meloidogyne incognita

To explore new skeleton with nematicidal activity, a series of novel 1,2,3-benzotriazin-4-one derivatives containing piperazine as linker were synthesized and varied fragments were also introduced to increase structure diversity of the new skeleton. Their inhibitory activities in vivo were evaluated against Meloidogyne incognita. The newly prepared compounds A6, A8, A21, A28 and A38 exhibited more than 50% inhibition at the concentration of 20 mg/L. Especially compound A6 displayed 71.4% inhibition against Meloidogyne incognita at the concentration of 20 mg/L. The nematicidal activities varied significantly depending on the types and positions of the substituents, which provided guidance for further structure modification.