36811-56-0

Basic information

• Product Name: N-[3-(2-chlorobenzoyl)thiophen-2-yl]glycinamide
• Synonyms: acetamide, 2-amino-N-[3-(2-chlorobenzoyl)-2-thienyl]-; N-[3-(2-Chlorobenzoyl)-2-thienyl]glycinamide
• CAS NO: 36811-56-0
• Molecular Formula: C₁₃H₁₁ClN₂O₂S
• Molecular Weight: 294.7566
• Mol File: 36811-56-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 556.5°C at 760 mmHg
• Flash Point: 290.3°C
• Density: 1.432g/cm³
• Vapor Pressure: 2.02E-12mmHg at 25°C
• Refractive Index: 1.673
• Solubility: DMSO, Ethyl Acetate, Methanol
• CAS DataBase Reference: N-[3-(2-chlorobenzoyl)thiophen-2-yl]glycinamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[3-(2-chlorobenzoyl)thiophen-2-yl]glycinamide(36811-56-0)
• EPA Substance Registry System: N-[3-(2-chlorobenzoyl)thiophen-2-yl]glycinamide(36811-56-0)

Safety Data

• Hazardous Substances Data: 36811-56-0(Hazardous Substances Data)

Usage

Description

N-[3-(2-chlorobenzoyl)thiophen-2-yl]glycinamide, also known as 2-Amino-N-(3-(2-chlorobenzoyl)thiophen-2-yl)acetamide, is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceuticals. It is characterized by its unique molecular structure, which includes a thiophenyl group and a chlorobenzoyl moiety, contributing to its potential applications in the medical field.

Uses

Used in Pharmaceutical Synthesis:
N-[3-(2-chlorobenzoyl)thiophen-2-yl]glycinamide is used as an intermediate in the synthesis of Brotizolam (B689280) for its role in veterinary medicine. Brotizolam is a hypnotic and sedative agent that is particularly effective as an appetite stimulant in animals, helping to improve their overall health and well-being.
Used in Veterinary Medicine:
In the veterinary industry, N-[3-(2-chlorobenzoyl)thiophen-2-yl]glycinamide is used as a key component in the production of Brotizolam, which is an essential medication for managing various health conditions in animals. Its application in this field highlights its importance in ensuring the welfare of animals under veterinary care.

Upstream product

• 53265-13-7 3-(2-Chlorobenzoyl)-2-(phtalimidoacetamido)thiophene 
• 40017-58-1 2-Amino-3-(o-chlorobenzoyl)-thiophene 
• 40017-59-2 [2-(2-chloro-acetylamino)-thiophen-3-yl]-(2-chloro-phenyl)-methanone 

Downstream Products

• 36811-58-2 5-(2-chlorophenyl)-1,3-dihydro-2H-thieno[2,3-e][4,1]diazepin-2-one 
• 40017-58-1 2-Amino-3-(o-chlorobenzoyl)-thiophene 
• 57801-83-9 7-Bromo-5-(2-chlorophenyl)-2-hydrazino-1,3-dihydrothieno<2,3-e>-1,4-diazepin-2-one 
• 40017-65-0 7-Bromo-5-(2-chlorophenyl)-1,3-dihydrothieno<2,3-e>-1,4-diazepin-2-one 
• 57801-97-5 2-Bromo-4-(2-chlorophenyl)-6H-thieno<3,2-f>-1,2,4-triazolo<4,3-a>-1,4-diazepine 
• 57801-82-8 7-Bromo-5-(2-chlorophenyl)-1,3-dihydrothieno<2,3-e>-1,4-diazepin-2-thione 
• 55865-79-7 5-(2-chloro-phenyl)-1-methyl-4-oxy-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one 
• 55865-85-5 7-chloro-5-(2-chloro-phenyl)-1-methyl-4-oxy-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one 
• 36811-68-4 5-(2-chloro-phenyl)-1-methyl-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one 
• 36811-67-3 7-chloro-5-(2-chloro-phenyl)-1-methyl-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one 

Relevant articles and documents

Potential hypnotics and anxiolytics: Synthesis of 2-bromo-4- (2-chlorophenyl)-9-[4-(2-methoxyethyl)-piperazino]-6H-thieno[3,2- f]-1,2,4-triazolo[4,3-a]-1,4-diazepine and of some related compounds

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