40017-58-1

Basic information

• Product Name: 2-Amino-3-(2-chlorobenzoyl)thiophene
• Synonyms: 2-Amino-3-(2-chlorobenzoyl)thiophene;(2-Amino-3-thienyl)(2-chlorophenyl)methanone;(2-aMinothiophen-3-yl)(2-chlorophenyl)Methanone
• CAS NO: 40017-58-1
• Molecular Formula: C₁₁H₈ClNOS
• Molecular Weight: 237.70532
• Product Categories: Amines;Aromatics;Heterocycles;Miscellaneous Reagents;Sulfur & Selenium Compounds
• Mol File: 40017-58-1.mol
• Article Data: 2

Chemical Properties

• Melting Point: 137-139℃
• Boiling Point: 430.5 °C at 760 mmHg
• Flash Point: 214.2 °C
• Appearance: /
• Density: 1.388
• Vapor Pressure: 1.29E-07mmHg at 25°C
• Refractive Index: 1.664
• Solubility: Dichloromethane, Ethyl Acetate, Methanol
• CAS DataBase Reference: 2-Amino-3-(2-chlorobenzoyl)thiophene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-3-(2-chlorobenzoyl)thiophene(40017-58-1)
• EPA Substance Registry System: 2-Amino-3-(2-chlorobenzoyl)thiophene(40017-58-1)

Safety Data

• Hazardous Substances Data: 40017-58-1(Hazardous Substances Data)

Usage

Description

2-Amino-3-(2-chlorobenzoyl)thiophene is an organic compound characterized by its chemical structure that features a thiophene ring with an amino group at the 2nd position and a 2-chlorobenzoyl group attached at the 3rd position. It is a yellow solid and is known for its utility in the synthesis of various pharmaceutical compounds.

Uses

Used in Pharmaceutical Industry:
2-Amino-3-(2-chlorobenzoyl)thiophene is used as an intermediate in the synthesis of Brotizolam (B689280(M)), which is a hypnotic and sedative agent. Its role in the production process is crucial for creating the final compound that helps in inducing sleep and reducing anxiety.
Additionally, due to its chemical properties and structure, 2-Amino-3-(2-chlorobenzoyl)thiophene may have potential applications in other areas of the pharmaceutical industry, such as the development of new drugs with different therapeutic profiles. However, further research and development would be required to explore these possibilities.

InChI:InChI=1/C11H8ClNOS/c12-9-4-2-1-3-7(9)10(14)8-5-6-15-11(8)13/h1-6H,13H2

Upstream product

• 40018-26-6 1,4-dithiane-2,5-diol 
• 40018-25-5 2-Chlorobenzoyl acetonitrile 
• 36811-56-0 2-amino-N-[3-(2-chlorobenzoyl)thiophen-2-yl]acetamide 
• 53265-13-7 3-(2-Chlorobenzoyl)-2-(phtalimidoacetamido)thiophene 

Downstream Products

• 51687-30-0 4-(2-chloro-phenyl)-1H-thieno[2,3-d]pyrimidin-2-one 
• 130534-59-7 [3-(2-Chloro-benzoyl)-thiophen-2-yl]-carbamic acid tert-butyl ester 
• 53265-13-7 3-(2-Chlorobenzoyl)-2-(phtalimidoacetamido)thiophene 
• 57801-83-9 7-Bromo-5-(2-chlorophenyl)-2-hydrazino-1,3-dihydrothieno<2,3-e>-1,4-diazepin-2-one 
• 36811-56-0 2-amino-N-[3-(2-chlorobenzoyl)thiophen-2-yl]acetamide 
• 40017-65-0 7-Bromo-5-(2-chlorophenyl)-1,3-dihydrothieno<2,3-e>-1,4-diazepin-2-one 
• 57801-97-5 2-Bromo-4-(2-chlorophenyl)-6H-thieno<3,2-f>-1,2,4-triazolo<4,3-a>-1,4-diazepine 
• 36811-58-2 5-(2-chlorophenyl)-1,3-dihydro-2H-thieno[2,3-e][4,1]diazepin-2-one 
• 57801-82-8 7-Bromo-5-(2-chlorophenyl)-1,3-dihydrothieno<2,3-e>-1,4-diazepin-2-thione 
• 130534-67-7 5-(2-Chloro-phenyl)-1,5-dihydro-thieno[2,3-e][1,4]thiazepin-2-one 
• 130534-69-9 5-(2-Chloro-phenyl)-1,5-dihydro-thieno[2,3-e][1,4]thiazepine-2-thione 
• 130534-71-3 7-Bromo-5-(2-chloro-phenyl)-1,5-dihydro-thieno[2,3-e][1,4]thiazepine-2-thione 
• 130534-61-1 {3-[(2-Chloro-phenyl)-hydroxy-methyl]-thiophen-2-yl}-carbamic acid tert-butyl ester 
• 130534-72-4 4-(2-Chloro-phenyl)-9-methyl-4H,6H-1,5-dithia-7,8,9a-triaza-cyclopenta[e]azulene 

Relevant articles and documents

THE SYNTHESIS OF THIENOTRIAZOLOTHIAZEPINES

Some derivatives of thienotriazolothiazepine, a novel heteroazepine, were synthesized.These compounds showed anti-PAF activity.