369-18-6Relevant articles and documents
The phthaloyl chloride-induced conversion reactions of trinitrobenzene into nitroaryl halides
Lee, Woong Hee,Park, Gyoo Soon,Kim, Seok Chan
, p. 2820 - 2822 (2012/01/05)
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Elemental fluorine. Part 20. Direct fluorination of deactivated aromatic systems using microreactor techniques
Chambers, Richard D.,Fox, Mark A.,Sandford, Graham,Trmcic, Jelena,Goeta, Andres
, p. 29 - 33 (2008/03/13)
Continuous flow microreactor technology has been used for the direct fluorination of a range of deactivated di- and tri-substituted aromatic systems.
Synthesis of Aromatic Fluoro Compounds by Nucleophilic Exchange of Nitro Groups by Fluoride
Effenberger, Franz,Streicher, Willi
, p. 157 - 162 (2007/10/02)
The synthesis of aromatic fluoro compounds from the respective nitro compounds by nucleophilic substitution of nitrite by fluoride is described.Reasonable yields in case of nonactivated nitro compounds are only obtained if the nitrite formed in the reaction is eliminated by acylation. 1-Fluoro-3-nitrobenzene (2) was obtained from 1,3-dinitrobenzene (1), and 1-fluoro-3,5-dinitrobenzene (9) as well as 1,3-difluoro-5-nitrobenzene (10) from 1,3,5-trinitrobenzene (8) in yields up to 92percent by reaction of nitro compounds with potassium fluoride in sulfolane at 180-200 deg C in the presence of phthaloyl dichloride (6); 1,2-difluoro-4-nitrobenzene (12) was formed in 58percent yield from 2,4-dinitro-1-fluorobenzene (11) in the presence of pyromellitoyl tetrachloride (13).
