3695-02-1

Basic information

• Product Name: N-BENZYL-N-METHYL-P-TOLUENESULFONAMIDE
• Synonyms: N-BENZYL-N-METHYL-P-TOLUENESULFONAMIDE;N,4-Dimethyl-N-benzylbenzenesulfonamide;N-Benzyl-N,4-dimethylbenzenesulfonamide;N-Methyl-N-benzyl-p-toluenesulfonamide
• CAS NO: 3695-02-1
• Molecular Formula: C₁₅H₁₇NO₂S
• Molecular Weight: 275.36598
• Mol File: 3695-02-1.mol
• Article Data: 34

Chemical Properties

• Boiling Point: 419°Cat760mmHg
• Flash Point: 207.2°C
• Appearance: /
• Density: 1.187g/cm³
• Vapor Pressure: 3.15E-07mmHg at 25°C
• Refractive Index: 1.587
• CAS DataBase Reference: N-BENZYL-N-METHYL-P-TOLUENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-BENZYL-N-METHYL-P-TOLUENESULFONAMIDE(3695-02-1)
• EPA Substance Registry System: N-BENZYL-N-METHYL-P-TOLUENESULFONAMIDE(3695-02-1)

Safety Data

• Hazardous Substances Data: 3695-02-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H17NO2S/c1-13-8-10-15(11-9-13)19(17,18)16(2)12-14-6-4-3-5-7-14/h3-11H,12H2,1-2H3

Upstream product

• 1576-37-0 N-benzyl-p-toluenesulfonamide 
• 74-88-4 methyl iodide 
• 536-57-2 p-toluene sulfinic acid 
• 3555-71-3 N-benzyl-N-chloromethylamine 
• 100-39-0 benzyl bromide 
• 640-61-9 N-methyl-p-toluenesulfonylamide 
• 100-51-6 benzyl alcohol 
• 26827-38-3 benzyl 2,2,2-trichloroacetate 
• 100-44-7 benzyl chloride 
• 103-67-3 benzyl-methyl-amine 
• 98-59-9 p-toluenesulfonyl chloride 
• 53772-44-4 benzyloxydiphenylphosphine 
• 27238-06-8 N-benzyl-N-methylmethanesulfonamide 
• 100-46-9 benzylamine 

Downstream Products

• 103-67-3 benzyl-methyl-amine 
• 622-29-7 N-Benzylidenemethylamine 
• 5694-20-2 N-benzylidenemethylamine 
• 108-88-3 toluene 
• 17105-71-4 N-methyl-N-benzylformamide 
• 29823-47-0 N-benzyl-N-methylacetamide 
• 81616-14-0 tert-butyl N-benzyl-N-methylcarbamate 
• 197958-57-9 1-Benzyl-3,3-diisopropyl-1-methyl-urea 
• 19499-61-7 methyl-(3-nitro-benzyl)-amine 
• 115562-46-4 N-(2'-hydroxybenzyl)-N-methyl-4-toluenesulfonamide 

Relevant articles and documents

Hypervalent Iodine Mediated Sulfonamide Synthesis

A new metal-free sulfonylation reaction is described. The method takes advantage of the Umpolung reactivity and group-transfer properties of iodine(III) compounds, combining hypervalent iodine reagents and sulfinate salts to deliver a clean and mild transfer of sulfonyl groups to amines and anilines. A total of 25 sulfonamides was synthesised in up to 99 % yield, even on gram-scale. The reaction mechanism was investigated by ESI-MS and DFT calculations.

Synthesis of aromatic sulfonamides through a copper-catalyzed coupling of aryldiazonium tetrafluoroborates, DABCO·(SO2)2, and N-Chloroamines

A copper-catalyzed aminosulfonylation of aryldiazonium tetrafluoroborates, DABCO·(SO2)2, and N-chloroamines is described. This coupling reaction provides an efficient and simple approach to a wide range of sulfonamides in moderate to good yields under mild conditions. Mechanistic investigation suggests that a radical process and transition-metal catalysis are merged in this tandem reaction.

Preparation method for sulfonamide compound

The invention discloses a preparation method for a sulfonamide compound. The preparation method comprises the following steps: with NIS as an oxidizing agent and potassium tert-butoxide as a base, reacting formamide with sodium arylsulfinate in an organic solvent, and carrying out post-treatment after the reaction is completed so as to obtain the sulfonamide compound. The preparation method uses formamide and sodium arylsulfinate as substrates for synthesis of the sulfonamide compound; the raw materials for the reaction are cheap and easily available; and the preparation method is simple.