36951-54-9

Basic information

• Product Name: 5-bromo-1-(4-methoxyphenyl)-1H-tetrazole
• Synonyms: 5-bromo-1-(4-methoxyphenyl)-1H-tetrazole
• CAS NO: 36951-54-9
• Molecular Weight: 255.074
• Mol File: 36951-54-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-bromo-1-(4-methoxyphenyl)-1H-tetrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-1-(4-methoxyphenyl)-1H-tetrazole(36951-54-9)
• EPA Substance Registry System: 5-bromo-1-(4-methoxyphenyl)-1H-tetrazole(36951-54-9)

Safety Data

• Hazardous Substances Data: 36951-54-9(Hazardous Substances Data)

Upstream product

• 13980-76-2 1-(4-methoxyphenyl)-1H-tetrazole-5-thiol 
• 104-94-9 4-methoxy-aniline 

Downstream Products

• 1352545-35-7 5-(3,4,5-trimethoxyphenyl)-1-(4-methoxyphenyl)-1H-tetrazole 
• 57761-73-6 1-(4'-methoxyphenyl)-5-phenyl-1H-tetrazole 

Relevant articles and documents

6-NITRO-2,3-DIHYDROIMIDAZO[2,1-b]OXAZOLES AND A PROCESS FOR THE PREPARATION THEREOF

The present invention relates to newer generation of triazoles, tetrazoles, isoxazoles, urea and sulphonamide functionalities containing 6-nitro-2, 3-dihydronitroimidazooxazoles agents of formula 1, their method of preparation, and their use as drugs for

Synthesis and evaluation of 1,5-disubstituted tetrazoles as rigid analogues of combretastatin A-4 with potent antiproliferative and antitumor activity

Tubulin, the major structural component of microtubules, is a target for the development of anticancer agents. Two series of 1,5-diaryl substituted 1,2,3,4-tetrazoles were concisely synthesized, using a palladium-catalyzed cross-coupling reaction, and identified as potent antiproliferative agents and novel tubulin polymerization inhibitors that act at the colchicine site. SAR analysis indicated that compounds with a 4-ethoxyphenyl group at the N-1 or C-5 position of the 1,2,3,4-tetrazole ring exhibited maximal activity. Several of these compounds also had potent activity in inhibiting the growth of multidrug resistant cells overexpressing P-glycoprotein. Active compounds induced apoptosis through the mitochondrial pathway with activation of caspase-9 and caspase-3. Furthermore, compound 4l significantly reduced in vivo the growth of the HT-29 xenograft in a nude mouse model, suggesting that 4l is a promising new antimitotic agent with clinical potential.