57761-73-6

Basic information

• Product Name: 1-(4'-methoxyphenyl)-5-phenyl-1H-tetrazole
• Synonyms: 1-(4'-methoxyphenyl)-5-phenyl-1H-tetrazole
• CAS NO: 57761-73-6
• Molecular Weight: 252.275
• Mol File: 57761-73-6.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1-(4'-methoxyphenyl)-5-phenyl-1H-tetrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4'-methoxyphenyl)-5-phenyl-1H-tetrazole(57761-73-6)
• EPA Substance Registry System: 1-(4'-methoxyphenyl)-5-phenyl-1H-tetrazole(57761-73-6)

Safety Data

• Hazardous Substances Data: 57761-73-6(Hazardous Substances Data)

Upstream product

• 611-94-9 4-Methoxybenzophenone 
• 100-66-3 methoxybenzene 
• 24316-60-7 (4-methoxyphenyl)(phenyl)methanone oxime 
• 18039-42-4 5-Phenyl-1H-tetrazole 
• 459-64-3 4-methoxybenzenediazonium tetrafluoroborate 
• 36951-54-9 5-bromo-1-(4-methoxyphenyl)-1H-tetrazole 
• 98-80-6 phenylboronic acid 
• 21788-28-3 1-(4-methoxyphenyl)-1H-tetrazole 
• 104-94-9 4-methoxy-aniline 
• 7472-54-0 N-(p-methoxyphenyl)benzamide 
• 34918-74-6 N-(4-methoxyphenyl)benzimidoyl chloride 

Relevant articles and documents

Improved Schmidt synthesis of 1,5-disubstituted 1H-tetrazoles from ketones

On treatment with an excess of sodium azide in the presence of titanium(IV) chloride in boiling acetonitrile, both aliphatic and aromatic ketones are smoothly converted to 1,5-disubstituted 1H-tetrazoles in high yields.

Stereospecific synthesis of 1,5-disubstituted tetrazoles from ketoximes via a Beckmann rearrangement facilitated by diphenyl phosphorazidate

A novel method for the stereospecific synthesis of 1,5-disubstituted tetrazoles from ketoximes via the Beckmann rearrangement was developed using diphenyl phosphorazidate (DPPA) as both the oxime activator and azide source. Various ketoximes were transformed into the corresponding 1,5-disubstituted tetrazoles with exclusive trans-group migration and no E-Z isomerization of the ketoxime. This method enables the preparation of 1,5-disubstituted tetrazoles without using toxic or explosive azidation reagents.

Preparation method of 5-phenyl-1-(4-methoxy phenyl)-1H-tetrazole

The invention relates to a preparation method of 5-phenyl-1-(4-methoxy phenyl)-1H-tetrazole. The preparation method includes the steps of firstly, mixing 4-anisidine, water and fluoroboric acid aqueous solution, dropwisely adding sodium nitrite aqueous solution while stirring at 0-5 DEG C, then rising the temperature to room temperature, continuing the stirring reaction for 1-2 hours, and performing suction filtration to obtain 4-methoxy phenyl diazonium tetrafluoroborate; secondly, stirring and mixing 5-phenyl-1H-tetrazole, alkali and copper salt catalyst with solvent at the temperature from minus 5 DEG C to 5 DEG C, adding the 4-methoxy phenyl diazonium tetrafluoroborate in batch, allowing for reaction for 6-8 hours while stirring at the temperature from minus 5 DEG C to room temperature, extracting after the reaction, drying, evaporating to remove the solvent, and recrystallizing to obtain the 5-phenyl-1-(4-methoxy phenyl)-1H-tetrazole. The preparation method has the advantages that the method uses copper salt as the catalyst, the reaction time is shortened, and the yield is increased at the same time; the method is easy in initial raw material obtaining, low in cost, simple in reaction operation, short in reaction path, easy in industrial production and promising in application prospect.