37572-23-9

Basic information

• Product Name: 3-Amino-5-(4-methoxyphenyl)thiophene-2-carboxylic acid methyl ester
• Synonyms: METHYL 3-AMINO-5-(4-METHOXYPHENYL)THIOPHENE-2-CARBOXYLATE;3-AMINO-5-(4-METHOXYPHENYL)THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER;3-AMino-5-(4-Methoxyphenyl)thiophene-2-carboxylicacidMethyleste;3-Amino-5-(4-methoxyphenyl)thiophene-2-carboxylic acid methyl es
• CAS NO: 37572-23-9
• Molecular Formula: C₁₃H₁₃NO₃S
• Molecular Weight: 263.31
• EINECS: 201-215-5
• Mol File: 37572-23-9.mol
• Article Data: 11

Chemical Properties

• Melting Point: 187-190°C
• Boiling Point: 472.1 °C at 760 mmHg
• Flash Point: 239.3 °C
• Appearance: /
• Density: 1.263 g/cm³
• Vapor Pressure: 4.39E-09mmHg at 25°C
• Refractive Index: 1.606
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-Amino-5-(4-methoxyphenyl)thiophene-2-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-5-(4-methoxyphenyl)thiophene-2-carboxylic acid methyl ester(37572-23-9)
• EPA Substance Registry System: 3-Amino-5-(4-methoxyphenyl)thiophene-2-carboxylic acid methyl ester(37572-23-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 37572-23-9(Hazardous Substances Data)

Usage

General Description

3-Amino-5-(4-methoxyphenyl)thiophene-2-carboxylic acid methyl ester is a chemical compound with the molecular formula C13H13NO3S. It is a methyl ester derivative of 3-amino-5-(4-methoxyphenyl)thiophene-2-carboxylic acid, and is commonly used in organic synthesis and pharmaceutical research. The compound contains a thiophene ring with an amino group and a carboxylic acid functional group, as well as a methoxyphenyl substituent. It has been studied for its potential biological activities, including anti-inflammatory and anticancer properties. The compound may also be used in the development of new drugs and therapeutics.

InChI:InChI=1/C13H13NO3S/c1-16-9-5-3-8(4-6-9)11-7-10(14)12(18-11)13(15)17-2/h3-7H,14H2,1-2H3

Upstream product

• 57466-68-9 3-chloro-3-(4-methoxyphenyl)acrylonitrile 
• 2365-48-2 Methyl thioglycolate 
• 874479-16-0 (Z)-3-chloro-3-(4-methoxyphenyl)-2-propenenitrile 
• 68-12-2 N,N-dimethyl-formamide 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 67-56-1 methanol 
• 649757-53-9 3-amino-5-(4’-methoxyphenyl)thiophene-2-carboxylic acid 
• 107818-55-3 3-amino-5-bromo-thiophene-2-carboxylic acid methyl ester 
• 5720-07-0 4-methoxyphenylboronic acid 
• 22288-78-4 Methyl 3-aminothiophene-2-carboxylate 
• 79128-68-0 methyl 3-(2,2,2-trifluoroacetamido)thiophene-2-carboxylate 
• 852330-31-5 5-bromo-3-(2,2,2-trifluoracetamido)thiophene-2-carboxylic acid methyl ester 

Downstream Products

• 37572-05-7 2-methoxy-6-(4-methoxy-phenyl)-2-thioxo-1,2-dihydro-2λ⁵-thieno[3,2-d][1,3,2]thiazaphosphinine-4-thione 
• 649757-53-9 3-amino-5-(4’-methoxyphenyl)thiophene-2-carboxylic acid 
• 917597-47-8 methyl 3-{[(1E)-(dimethylamino)methylidene]amino}-5-[4-(methoxy)phenyl]-2-thiophenecarboxylate 
• 354812-16-1 3-amino-5-(4-methoxyphenyl)thiophene-2-carboxamide 
• 1585969-91-0 methyl 3-([1,1'-biphenyl]-4-ylcarboxamido)-5-(4-methoxyphenyl)thiophene-2-carboxylate 
• 1585969-84-1 3-([1,1'-biphenyl]-4-ylcarboxamido)-5-(4-methoxyphenyl)thiophene-2-carboxylic acid 

Relevant articles and documents

Combining in silico and biophysical methods for the development of pseudomonas aeruginosa quorum sensing inhibitors: An alternative approach for structure-based drug design

The present work deals with the optimization of an inhibitor of PqsD, an enzyme essential for Pseudomonas aeruginosa quorum sensing apparatus. Molecular docking studies, supported by biophysical methods (surface plasmon resonance, isothermal titration cal

NOVEL THIENO[3,2-B]PYRIDINE-5(4H)-ONE DERIVATIVE COMPOUND, PREPARATION METHOD THEREOF AND USE THEREOF

The present invention relates to a novel thieno[3,2-b]pyridine-5(4H)-one derivative compound, a preparation method thereof, and a use thereof. The novel thieno[3,2-b]pyridine-5(4H)-one derivative compound according to the present invention is synthesized via an aza-[3+3] cyclization addition reaction using BOP, wherein the compound is obtained by synthesizing a 4-arylthiophen-3-amine in which aryl groups such as 4-piperidyl-C6H4, 4-pyrrolidyl-C6H4, 4-MeOC6H4, 3,4,5-(MeO)3C6H4, C6H5, 4-C6H5C6H4, and 4-F3COC6H4 are introduced via a synthesis process by a bromination reaction, a hydrolysis reaction, a decarboxylation reaction, and a Suzuki coupling reaction of methyl 3-aminothiophene carboxylate, and by synthesizing 4-arylthiophen-3-amine and mono-methyl fumarate via a formal aza-[3+3] cyclization addition reaction using BOP and conjugation. Accordingly, novel thieno[3,2-b]pyridine-5(4H)-one derivative compounds according to the present invention have fluorescence properties with a wide range of emission wavelengths and thus may be utilized in various industrial fields such as physics, chemistry, and biomedical research.

Exploring the chemical space of ureidothiophene-2-carboxylic acids as inhibitors of the quorum sensing enzyme PqsD from Pseudomonas aeruginosa

Pseudomonas aeruginosa employs a quorum sensing (QS) communication system that makes use of small diffusible molecules. Among other effects, the QS system coordinates the formation of biofilm which decisively contributes to difficulties in the therapy of