649757-53-9

Basic information

• Product Name: 2-Thiophenecarboxylic acid, 3-amino-5-(4-methoxyphenyl)-
• CAS NO: 649757-53-9
• Molecular Formula: C12H11NO3S
• Molecular Weight: 249.29
• Mol File: 649757-53-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-Thiophenecarboxylic acid, 3-amino-5-(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiophenecarboxylic acid, 3-amino-5-(4-methoxyphenyl)-(649757-53-9)
• EPA Substance Registry System: 2-Thiophenecarboxylic acid, 3-amino-5-(4-methoxyphenyl)-(649757-53-9)

Safety Data

• Hazardous Substances Data: 649757-53-9(Hazardous Substances Data)

Upstream product

• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 57466-68-9 3-chloro-3-(4-methoxyphenyl)acrylonitrile 
• 37572-23-9 3-amino-5-(4-methoxyphenyl)thiophene-2-carboxylic acid methyl ester 

Downstream Products

• 1585969-84-1 3-([1,1'-biphenyl]-4-ylcarboxamido)-5-(4-methoxyphenyl)thiophene-2-carboxylic acid 
• 1585969-91-0 methyl 3-([1,1'-biphenyl]-4-ylcarboxamido)-5-(4-methoxyphenyl)thiophene-2-carboxylate 
• 37572-23-9 3-amino-5-(4-methoxyphenyl)thiophene-2-carboxylic acid methyl ester 
• 1428907-31-6 9-chloro-2-(4-methoxyphenyl)-5,6,7,8-tetrahydrothieno[3,2-b]quinoline 
• 1258958-23-4 N-(4-methoxyphenyl)-N'-[5-(4-methoxyphenyl)-3-thienyl]thiourea 
• 1258958-17-6 3-isothiocyanato-5-(4-methoxyphenyl)thiophene 

Relevant articles and documents

Exploring the chemical space of ureidothiophene-2-carboxylic acids as inhibitors of the quorum sensing enzyme PqsD from Pseudomonas aeruginosa

Pseudomonas aeruginosa employs a quorum sensing (QS) communication system that makes use of small diffusible molecules. Among other effects, the QS system coordinates the formation of biofilm which decisively contributes to difficulties in the therapy of

Combining in silico and biophysical methods for the development of pseudomonas aeruginosa quorum sensing inhibitors: An alternative approach for structure-based drug design

The present work deals with the optimization of an inhibitor of PqsD, an enzyme essential for Pseudomonas aeruginosa quorum sensing apparatus. Molecular docking studies, supported by biophysical methods (surface plasmon resonance, isothermal titration cal

Hit-to-lead studies: The discovery of potent, orally active, thiophenecarboxamide IKK-2 inhibitors

A hit-to-lead optimisation programme was carried out on the thiophenecarboxamide high throughput screening hits 1 and 2 resulting in the discovery of the potent and orally bioavailable IKK-2 inhibitor 22.