3760-95-0

Basic information

• Product Name: (R)-(+)-1,2-Epoxybutane
• Synonyms: (2R)-(+)-1,2-Epoxybutane, (2R)-(+)-2-Ethyloxirane;(2R)-(+)-3-Methyl-1,2-propenoxide 98+%;(R)-()-1,2-Butylene oxide;Oxirane, 2-ethyl-,(2R)-;(R)-(+)-1,2-Epoxybutane 98%;(R)-(+)-1,2-EPOXYBUTANE;(R)-1,2-EPOXYBUTANE;2R-ETHYLOXIRANE
• CAS NO: 3760-95-0
• Molecular Formula: C₄H₈O
• Molecular Weight: 72.11
• Product Categories: Chiral Compounds;Epoxides;API intermediates
• Mol File: 3760-95-0.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 63 °C(lit.)
• Flash Point: 10 °F
• Appearance: /
• Density: 0.837 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.386(lit.)
• CAS DataBase Reference: (R)-(+)-1,2-Epoxybutane(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-1,2-Epoxybutane(3760-95-0)
• EPA Substance Registry System: (R)-(+)-1,2-Epoxybutane(3760-95-0)

Safety Data

• Hazard Codes: F,T
• Statements: 20/21/22-34-40
• Safety Statements: 16-26-27-36/37/39-45
• RIDADR: UN 3022 3/PG 2
• WGK Germany: 3
• HazardClass: 3
• PackingGroup: II
• Hazardous Substances Data: 3760-95-0(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

Upstream product

• 106-88-7 ethyloxirane 
• 70379-72-5 (R)-2-acetoxy-1-bromobutane 
• 40348-66-1 (R)-1,2-butanediol 
• 93246-17-4 ((R)-2-Hydroxy-butyl)-trimethyl-ammonium; hydroxide 
• 136656-75-2 (R)-(-)-1-(benzenesulfanyl)-2-butanol 
• 72952-76-2 S-(-)-1-bromo-2-acetoxy-butane 
• 145021-04-1 (R)-1-tert-Butylsulfanyl-butan-2-ol 
• 56536-49-3 (2S)-2-chlorobutan-1-ol 
• 51-79-6 urethane 
• 917-61-3 sodium isocyanate 
• 124-38-9 carbon dioxide 

Downstream Products

• 16460-75-6 (R)-2-phenyl-butan-1-ol 
• 2031-46-1 (3S)-3-phenylbutan-1-ol 
• 1873-25-2 1-chloro-butan-2-ol 
• 89479-94-7 (R)(-)-1-N-benzylaminobutan-2-ol 
• 93246-19-6 (R)-2-(3,5-Bisphenyl)-2-(2-hydroxybutyl)-1,3-dithiane 
• 13552-21-1 (R)(-)-1-aminobutan-2-ol 
• 198561-27-2 (R)-3-hydroxypentanenitrile 
• 4221-99-2 (S)-2-butanol 
• 71-36-3 butan-1-ol 
• 1092363-41-1 (R)-N-(2-hydroxybutyl)-4-methylbenzenesulfonamide 
• 1087160-39-1 C₁₅H₁₃BrF₅N₃O₂ 

Relevant articles and documents

Aromatic Donor-Acceptor Interaction-Based Co(III)-salen Self-Assemblies and Their Applications in Asymmetric Ring Opening of Epoxides

Aromatic donor-acceptor interaction as the driving force to assemble cooperative catalysts is described. Pyrene/naphthalenediimide functionalized Co(III)-salen complexes self-assembled into bimetallic catalysts through aromatic donor-acceptor interactions and showed high catalytic activity and selectivity in the asymmetric ring opening of various epoxides. Control experiments, nuclear magnetic resonance (NMR) spectroscopy titrations, mass spectrometry measurement, and X-ray crystal structure analysis confirmed that the catalysts assembled based on the aromatic donor-acceptor interaction, which can be a valuable noncovalent interaction in supramolecular catalyst development.

OXYSTEROLS AND METHODS OF USE THEREOF

Compounds are provided according to Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R2, R3, R4, R5, and and R6 are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.

Chiral oligomers of spiro-salencobalt(III)X for catalytic asymmetric cycloaddition of epoxides with CO2

Several new chiral oligomers of spiro-salenCo(III)X (spiro = 1.1′-spirobiindane-7.7′-diol) complexes have been designed, synthesized, and characterized by nuclear magnetic resonance (NMR), infrared (IR), and elemental analyses, in which, the chiral spiro moieties are first introduced into a scaffold of chiral salenCo catalysts. They were used to catalyze the asymmetric cycloaddition of epoxides with carbon dioxide. Under very mild reaction conditions, a kinetic resolution of racemic epoxides with CO2 was smoothly initiated by these chiral oligomer catalysts with good enantioselectivities, which can be attributed to the match effect between chiral backbones of salen and spiro. High stability and easy recyclability are their major advantages.