37795-81-6Relevant articles and documents
2,3 Dihydro 9H isoxazolo[3,2 b]quinazolin 9 ones and 3,4 dihydro (1,2) oxazino[3,2 b]quinazolin 10(2H) ones
Reisner,Ludwig,Simon,Dejneka,Sofia
, p. 766 - 770 (2007/10/09)
Two series of compounds, 2,3-dihydro-9H-isoxazolo [3,2-b] quinazolin-9-ones and 3,4-dihydro-(1,2)-oxazino-[3,2-b]quinazolin-10 (2H)-ones, were synthesized and evaluated for anti-inflammatory, antipyretic and analgesic activity. The isoxazolo compounds were generally more active than their oxazino homologs. Three compounds, i.e., 2,3-dihydro 9H isoxazolo [3,2-b]quinazolin-9-one (W-2429) and its 2- and 3-methyl congeners, were the most active of all compounds tested in this study. On the basis of the biological results herein reported, W-2429 is considerably more effective than acetylsalicylic acid in inhibiting carrageenan-induced edema and in reducing brewer's yeast-induced fever in rats. Also, it was found to be more potent than propoxyphene hydrochloride in the Randall-Selitto test for analgesic activity.