38041-19-9Relevant articles and documents
Synthesis method for 4-Aaminotetrahydropyran synthesis
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Paragraph 0021; 0029; 0034; 0034; 0037; 0038; 0039-0041, (2018/06/23)
The invention discloses a synthesis method for 4-aminotetrahydropyran. The method comprises the steps that tetrahydro-2H-pyran-4-carboxylic acid is dissolved in water, the temperature is increased to60-70 DEC G by heating, ammonia water is added dropwisely under the condition of stirring, stirring reaction is conducted for 1-2 hours after dropwise adding is completed, the temperature is decreasedto the room temperature after the reaction is completed to obtain tetrahydro-2H-pyran-4-carboxamide mixed solution; cooling is conducted on the prepared tetrahydro-2H-pyran-4-carboxamide mixed solution to reduce the temperature to 5-10 DEC G, NaOH solution is added, NaBrO solution is added dropwisely in the mixed solution after the mixed solution is stirred uniformly, after the dropwise adding iscompleted, the reaction is performed constantly for 1-2 hours under the temperature of 5-10 DEC G, the temperature is decreased to the room temperature after the temperature is increased to 50-60 DECG to perform the reaction constantly for 1 hour, extraction is conducted by using dichloromethane, an organic phase is combined, and after the dichloromethane is removed by distillation through reducing pressure, recrystallization is conducted to obtain the 4-aminotetrahydropyran. The method has the advantages of being simple to operate, mild in condition, less in byproducts, high in product purity, and higher in product yield.
4-Aminotetrahydropyrans process for one-pot synthesis
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Paragraph 0014; 0015, (2017/02/02)
The invention discloses a one-kettle method synthesis process of 4-aminotetrahydropyran. The synthesis process comprises the following steps: synthesizing 4-carboxamide tetrahydropyran by taking 4-cyano-tetrahydropyran and a sodium hydroxide solution (or a potassium hydroxide solution) as raw materials, further slowly adding a sodium hypochlorite solution (or a sodium hypobromite solution) into 4-carboxamide tetrahydropyran, then heating till reflux, and performing decarboxylation to generate a product, namely 4-aminotetrahydropyran. All the reaction raw materials are placed into one kettle for reaction, the appropriate reaction conditions are selected for synthesizing 4-aminotetrahydropyran, and the synthesis process has the advantages of high selectivity, few impurities, no need of separating intermediate products, high yield and high practical value.
IMIDAZO [1, 2 - B] PYRIDAZINE - BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND USES THEREOF
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Page/Page column 29, (2013/09/26)
Imidazo[1,2-b]pyridazine-based compounds of the formula (I): are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.