38180-46-0 Usage
Description
2-Cyano-3-chloropyridine, with the CAS number 38180-46-0, is a light yellow solid compound that is widely utilized in the field of organic synthesis. It is known for its unique chemical properties that make it a valuable component in the creation of various organic compounds.
Uses
Used in Organic Synthesis:
2-Cyano-3-chloropyridine is used as a key intermediate for the synthesis of various organic compounds. Its chemical structure, which includes a cyano group and a chloro substituent on the pyridine ring, allows it to participate in a range of reactions, such as nucleophilic substitution, addition, and cyclization, leading to the formation of diverse organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Cyano-3-chloropyridine is used as a building block for the development of new drugs. Its unique chemical properties enable the creation of novel drug candidates with potential therapeutic applications, such as antibiotics, antivirals, and anticancer agents.
Used in Agrochemical Industry:
2-Cyano-3-chloropyridine is also employed in the agrochemical industry for the synthesis of various pesticides and herbicides. Its reactivity and structural diversity make it a valuable component in the development of new compounds with improved efficacy and selectivity against target pests and weeds.
Used in Dye and Pigment Industry:
In the dye and pigment industry, 2-Cyano-3-chloropyridine is utilized as a starting material for the synthesis of various dyes and pigments. Its chemical properties allow for the creation of a wide range of colored compounds with different shades and hues, which can be used in various applications, such as textiles, plastics, and printing inks.
Used in Material Science:
2-Cyano-3-chloropyridine is also used in the field of material science for the development of new materials with specific properties. Its unique chemical structure can be exploited to create novel polymers, coatings, and other materials with enhanced performance characteristics, such as improved thermal stability, mechanical strength, and chemical resistance.
Check Digit Verification of cas no
The CAS Registry Mumber 38180-46-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,1,8 and 0 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 38180-46:
(7*3)+(6*8)+(5*1)+(4*8)+(3*0)+(2*4)+(1*6)=120
120 % 10 = 0
So 38180-46-0 is a valid CAS Registry Number.
InChI:InChI=1/C6H3ClN2/c7-5-2-1-3-9-6(5)4-8/h1-3H
38180-46-0Relevant articles and documents
C?H Cyanation of 6-Ring N-Containing Heteroaromatics
Elbert, Bryony L.,Farley, Alistair J. M.,Gorman, Timothy W.,Johnson, Tarn C.,Genicot, Christophe,Lallemand, Bénédicte,Pasau, Patrick,Flasz, Jakub,Castro, José L.,MacCoss, Malcolm,Paton, Robert S.,Schofield, Christopher J.,Smith, Martin D.,Willis, Michael C.,Dixon, Darren J.
supporting information, p. 14733 - 14737 (2017/10/07)
Heteroaromatic nitriles are important compounds in drug discovery, both for their prevalence in the clinic and due to the diverse range of transformations they can undergo. As such, efficient and reliable methods to access them have the potential for far-reaching impact across synthetic chemistry and the biomedical sciences. Herein, we report an approach to heteroaromatic C?H cyanation through triflic anhydride activation, nucleophilic addition of cyanide, followed by elimination of trifluoromethanesulfinate to regenerate the cyanated heteroaromatic ring. This one-pot protocol is simple to perform, is applicable to a broad range of decorated 6-ring N-containing heterocycles, and has been shown to be suitable for late-stage functionalization of complex drug-like architectures.
REGIOSELECTIVE CYANATION OF 3-SUBSTITUTED PYRIDINE 1-OXIDES
Fife, Wilmer K.
, p. 93 - 96 (2007/10/02)
Cyanation of 3-X-pyridine 1-oxides with trimethylsilanecarbonitrile and dimethylcarbamoyl chloride occurs quantitatively to give 3-X-pyridinecarbonitriles in > 90percent isolated yields when X = -CH3, -OCH3, -OH and -Cl, and approximately equal amounts of the 3- and 5-X derivatives when X = -CN and -COOCH3.
