38449-59-1Relevant articles and documents
Tetrahydroisoquinoline compound as estrogen receptor and histone deacetylase double-target compound, and synthesis method and application thereof
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Paragraph 0039-0043; 0052-0056, (2021/06/26)
The invention discloses a tetrahydroisoquinoline compound as an estrogen receptor and histone deacetylase double-target compound as well as a synthesis method and application of the tetrahydroisoquinoline compound. The compound can target an estrogen rece
One-pot chemoenzymatic synthesis of trolline and tetrahydroisoquinoline analogues
Zhao, Jianxiong,Lichman, Benjamin R.,Ward, John M.,Hailes, Helen C.
, p. 1323 - 1326 (2018/02/14)
Chemoenzymatic reaction cascades can provide access to chiral compounds from low-cost starting materials in one pot. Here we describe one-pot asymmetric routes to tetrahydroisoquinoline alkaloids (THIAs) using the Pictet-Spenglerase norcoclaurine synthase (NCS) followed by a cyclisation, to give alkaloids with two new heterocyclic rings. These reactions operated with a high atom economy to generate THIAs in high yields.
Synthesis and structure activity relationship of tetrahydroisoquinoline- based potentiators of GluN2C and GluN2D containing N-Methyl-D-aspartate receptors
Santangelo Freel, Rose M.,Ogden, Kevin K.,Strong, Katie L.,Khatri, Alpa,Chepiga, Kathryn M.,Jensen, Henrik S.,Traynelis, Stephen F.,Liotta, Dennis C.
, p. 5351 - 5381 (2013/07/26)
We describe here the synthesis and evaluation of a series of tetrahydroisoquinolines that show subunit-selective potentiation of NMDA receptors containing the GluN2C or GluN2D subunits. Bischler-Napieralski conditions were employed in the key step for the