91523-50-1 Usage
Description
6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid is a chemical compound that belongs to the isoquinoline family. It is characterized by the presence of a hydroxyl group at the 6-position and a carboxylic acid group at the 1-position. 6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid is of interest in the field of medicinal chemistry due to its potential applications in the development of therapeutic agents.
Uses
Used in Pharmaceutical Research:
6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid is used as a key intermediate in the synthesis of proline-containing peptides. These peptides have potential applications as caspase-2 inhibitors, which are important targets in the development of drugs for the treatment of various diseases, including cancer and neurodegenerative disorders.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid serves as a valuable building block for the design and synthesis of novel bioactive compounds. Its unique structural features allow for the development of molecules with specific biological activities, making it a promising candidate for further research and drug discovery efforts.
Used in Drug Development:
6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid is utilized in the development of new drugs targeting caspase-2, an enzyme involved in the regulation of apoptosis. Inhibition of caspase-2 has been shown to have potential therapeutic benefits in the treatment of diseases characterized by uncontrolled cell death, such as neurodegenerative disorders and certain types of cancer.
Used in Biochemical Studies:
6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid is also used in biochemical studies to investigate the mechanisms of caspase-2 inhibition and its role in cellular processes. Understanding the interactions between 6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid and caspase-2 can provide valuable insights into the development of more effective and targeted therapies for various diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 91523-50-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,1,5,2 and 3 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 91523-50:
(7*9)+(6*1)+(5*5)+(4*2)+(3*3)+(2*5)+(1*0)=121
121 % 10 = 1
So 91523-50-1 is a valid CAS Registry Number.
InChI:InChI=1/C10H11NO3/c12-7-1-2-8-6(5-7)3-4-11-9(8)10(13)14/h1-2,5,9,11-12H,3-4H2,(H,13,14)
91523-50-1Relevant articles and documents
Synthesis of novel (benzimidazolyl)isoquinolinols and evaluation as adenosine A1 receptor tools
Singh, Sameek,Cooper, Samantha L.,Glenn, Jacqueline R.,Beresford, Jessica,Percival, Lydia R.,Tyndall, Joel D. A.,Hill, Stephen J.,Kilpatrick, Laura E.,Vernall, Andrea J.
, p. 16362 - 16369 (2018/05/22)
G protein-coupled receptors (GPCRs) constitute the largest family of transmembrane receptors in eukaryotes. The adenosine A1 receptor (A1AR) is a class A GPCR that is of interest as a therapeutic target particularly in the treatment of cardiovascular disease and neuropathic pain. Increased knowledge of the role A1AR plays in mediating these pathophysiological processes will help realise the therapeutic potential of this receptor. There is a lack of enabling tools such as selective fluorescent probes to study A1AR, therefore we designed a series of (benzimidazolyl)isoquinolinols conjugated to a fluorescent dye (31-35, 42-43). An improved procedure for the synthesis of isoquinolinols from tetrahydroisoquinolinols via oxidation with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and atmospheric oxygen is reported. This synthetic method offers advantages over previous metal-based methods for the preparation of isoquinolinols and isoquinolines, which are important scaffolds found in many biologically active compounds and natural products. We report the first synthesis of the (benzimidazolyl)isoquinolinol compound class, however the fluorescent conjugates were not successful as A1AR fluorescent ligands.
Tetrahydroisoquinoline 1-carboxamides as growth hormone secretagogues
Li, James J.,Wang, Haixia,Qu, Fucheng,Musial, Christa,Tino, Joseph A.,Robl, Jeffrey A.,Slusarchyk, Dorothy,Golla, Rajasree,Seethala, Ramakrishna,Dickinson, Kenneth,Giupponi, Leah,Grover, Gary,Sleph, Paul,Flynn, Neil,Murphy, Brian J.,Gordon, David,Kung, Melissa,Stoffel, Robert
, p. 1799 - 1802 (2007/10/03)
Several novel series of tetrahydroisoquinoline 1-carboxamides were prepared and shown to be potent growth hormone (GH) secretagogues. Among them, carbamate 12a-E2 displays excellent in vivo activity by increasing plasma GH 10-fold in an anesthetized IV rat model.
Tetrahydroisoquinoline analogs as modulators of chemokine receptor activity
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Page/Page column 38, (2010/11/29)
Tetrahydroisoquinoline analogs are provided which are modulators of chemokine receptor activity. The tetrahdroisoquinoline analogs thereof have the structure wherein R1, R2, R3, R3a, X1, X2, X3, X4, m, n and p are as described herein.
