350014-19-6

Basic information

• Product Name: 2-tert-butyl 1-methyl 6-hydroxy-3,4-dihydroisoquinoline-1,2(1H)-dicarboxylate
• Synonyms: 2-tert-butyl 1-methyl 6-hydroxy-3,4-dihydroisoquinoline-1,2(1H)-dicarboxylate;2-tert-butyl 1-methyl 3,4-dihydro-6-hydroxyisoquinoline-1,2(1H)-dicarboxylate
• CAS NO: 350014-19-6
• Molecular Formula: C₁₆H₂₁NO₅
• Molecular Weight: 307.34164
• Mol File: 350014-19-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-tert-butyl 1-methyl 6-hydroxy-3,4-dihydroisoquinoline-1,2(1H)-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-tert-butyl 1-methyl 6-hydroxy-3,4-dihydroisoquinoline-1,2(1H)-dicarboxylate(350014-19-6)
• EPA Substance Registry System: 2-tert-butyl 1-methyl 6-hydroxy-3,4-dihydroisoquinoline-1,2(1H)-dicarboxylate(350014-19-6)

Safety Data

• Hazardous Substances Data: 350014-19-6(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 350014-18-5 1,2,3,4-Tetrahydro-6-hydroxy-1-isoquinolinecarboxylic acid methyl ester 
• 77-78-1 dimethyl sulfate 
• 362492-00-0 2-(tert-butoxycarbonyl)-6-hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid 
• 588-05-6 m-tyramine 
• 91523-50-1 rac-6-hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid 
• 1068562-72-0 C₂₁H₂₉NO₇ 
• 38449-59-1 2-(3-hydroxyphenyl)ethylamine hydrobromide 
• 2039-67-0 2-(3-methoxyphenyl)-1-ethanamine 

Downstream Products

• 350014-20-9 3,4-Dihydro-6-(phenylmethoxy)-1,2(1H)-isoquinolinedicarboxylic acid 1-methyl 2-(1,1-dimethylethyl) ester 
• 362492-00-0 2-(tert-butoxycarbonyl)-6-hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid 
• 373638-25-6 6-benzyloxy-3,4-dihydro-1H-isoquinoline-1,2-dicarboxylic acid 2-tert-butyl ester 
• 373638-29-0 6-benzyloxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid (2-diisopropylamino-ethyl)-amide 
• 373637-06-0 1-(2-diisopropylamino-ethylcarbamoyl)-6-phenoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 
• 373633-77-3 1-[[[2-[Bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2(1H)-isoquinoline-carboxylic acid,1,1-dimethylethyl ester 
• 1430216-07-1 (E)-4-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-6-(2-methoxyethoxy)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid 

Relevant articles and documents

Enzymatic resolution of methyl (1RS)-N-tBoc-6-hydroxy-3,4-dihydro-1H-isoquinoline-1-carboxylate by Seaprose S

An efficient biocatalytic process has been developed for the resolution of methyl (1RS)-N-tBoc-6-hydroxy-3,4-dihydro-1H-isoquinoline-1-carboxylate rac-1 by means of Seaprose S-mediated enantioselective hydrolysis to afford (1S)-2 and (1R)-1 in 87% and 93% isolated yield, 101% and 96% potency, and ee >99.8% and >99.5%, respectively.

Tetrahydroisoquinoline 1-carboxamides as growth hormone secretagogues

Several novel series of tetrahydroisoquinoline 1-carboxamides were prepared and shown to be potent growth hormone (GH) secretagogues. Among them, carbamate 12a-E2 displays excellent in vivo activity by increasing plasma GH 10-fold in an anesthetized IV rat model.

Lactam derivatives as antiarrhythmic agents

Lactam derivatives of the formula where X is —C(═O)NR3′—, —NR3′C(═O)—, —C(═NCN)NR3′—, —NR3′C(═NCN)—, —CH2NR3′—, —CH(alkyl)NR3′—, —CH(COOalkyl)NR3′—, —CH(CH2