386273-52-5Relevant articles and documents
Preparation method and application of N-(pyrimidine-2-yl) coumarin-7-amine derivative as protein kinase inhibitor
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Paragraph 0647; 0650-0652, (2020/12/14)
The invention discloses a cyclin-dependent kinase inhibitor. The cyclin-dependent kinase inhibitor comprises an N-(pyrimidine-2-yl) coumarin-7-amine derivative shown as a general formula (I). In-vitropharmacodynamic tests prove that the compound has a high-selectivity inhibition effect on CDK9 kinase, and can be applied to reducing or inhibiting the activity of CDK9 kinase in cells. The inventionalso discloses a preparation method of the inhibitor and application of the inhibitor in drugs for CDK family kinase mediated diseases, especially hyperproliferative diseases, virus-induced infectious diseases and cardiovascular diseases.
New constrained "molecular tongs" designed to dissociate HIV-1 protease dimer
Merabet, Naima,Dumond, Julien,Collinet, Bruno,Van Baelinghem, Laurence,Boggetto, Nicole,Ongeri, Sandrine,Ressad, Fariza,Reboud-Ravaux, Michèle,Sicsic, Sames
, p. 6392 - 6400 (2007/10/03)
New "molecular tongs" based on naphthalene and quinoline scaffolds linked to two peptidic strands were synthesized. They were designed to prevent dimerization of HIV-1 protease by targeting the antiparallel β-sheet involving N- and C-termini of each monom
