389634-81-5

Basic information

• Product Name: Phenylalanine, 4-fluoro-N-formyl-3-nitro-, ethyl ester
• CAS NO: 389634-81-5
• Molecular Formula: C12H13FN2O5
• Molecular Weight: 284.244
• Mol File: 389634-81-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Phenylalanine, 4-fluoro-N-formyl-3-nitro-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phenylalanine, 4-fluoro-N-formyl-3-nitro-, ethyl ester(389634-81-5)
• EPA Substance Registry System: Phenylalanine, 4-fluoro-N-formyl-3-nitro-, ethyl ester(389634-81-5)

Safety Data

• Hazardous Substances Data: 389634-81-5(Hazardous Substances Data)

Upstream product

• 20274-69-5 (4-fluoro-3-nitrophenyl)methanol 
• 42564-51-2 4-fluoro-3-nitrobenzaldehyde 
• 459-57-4 4-fluorobenzaldehyde 
• 15017-52-4 4-(bromomethyl)-1-fluoro-2-nitrobenzene 
• 389634-80-4 2-(4-fluoro-3-nitro-benzyl)-2-formylamino-malonic acid diethyl ester 

Downstream Products

• 604004-13-9 2-(2-{Butyl-[2-(3-hydroxy-phenyl)-acetyl]-amino}-octanoylamino)-3-(4-fluoro-3-nitro-phenyl)-propionic acid 
• 389634-83-7 2-(2-{Butyl-[2-(3-hydroxy-phenyl)-acetyl]-amino}-octanoylamino)-3-(4-fluoro-3-nitro-phenyl)-propionic acid ethyl ester 
• 627535-85-7 3-(4-Fluoro-3-nitro-phenyl)-2-{2-[[2-(3-hydroxy-phenyl)-acetyl]-(4-methoxy-phenyl)-amino]-2-phenyl-acetylamino}-propionic acid ethyl ester 
• 390360-63-1 10-(4-methoxy-phenyl)-19-nitro-9,12-dioxo-11-phenyl-2-oxa-10,13-diaza-tricyclo[14.2.2.1^3,7]heneicosa-1⁽¹⁹⁾,3,5,7⁽²¹⁾,16⁽²⁰⁾,17-hexaene-14-carboxylic acid ethyl ester 
• 389635-04-5 9,12-dioxo-2-oxa-10-(4'-methoxyphenyl)-11-phenyl-14-ethoxycarbonyl-18-amino-10,13-diazatricyclo[14.2.2.1^3,7]heneicosa-3,5,7⁽²¹⁾,16,18,19-hexaene 
• 604004-12-8 3-(4-fluoro-3-nitro-phenyl)-2-formylamino-propionic acid 

Relevant articles and documents

A rapid access to biaryl ether containing macrocycles by pairwise use of Ugi 4CR and intramolecular S(N)Ar-based cycloetherification.

[reaction: see text] From readily accessible starting materials, macrocycles with an endo aryl-aryl ether bond are synthesized in only two operations by combination of the Ugi four-component reaction and an intramolecular S(N)Ar reaction. The nitro group serves as an activator for the macrocyclization and provides a handle for the introduction of functional group diversity. A Ugi reaction promoted by ammonium chloride in aprotic solvent is documented for the first time.