38969-40-3 Usage
Description
ECGONINE METHYL ESTER HYDROCHLORIDE, also known as (-)-Ecgonine Methyl Ester, is a methyl ester derivative of (-)-Ecgonine (E325550) and an important metabolite of Cocaine (C633500). It is classified as a controlled substance due to its association with cocaine.
Uses
Used in Pharmaceutical Industry:
ECGONINE METHYL ESTER HYDROCHLORIDE is used as an intermediate compound for the synthesis of various pharmaceutical products. Its role in the synthesis process is crucial for developing medications with potential therapeutic applications.
Used in Research and Development:
In the field of research and development, ECGONINE METHYL ESTER HYDROCHLORIDE serves as a valuable compound for studying the properties and effects of its parent compound, cocaine, and its derivatives. This helps in understanding the mechanisms of action, potential risks, and benefits associated with cocaine and its related substances.
Used in Forensic Science:
ECGONINE METHYL ESTER HYDROCHLORIDE is utilized as a reference material in forensic science for the identification and analysis of cocaine and its metabolites in biological samples. This aids in the investigation of drug-related crimes and the assessment of drug use in individuals.
Used in Controlled Substance Regulation:
As a controlled substance, ECGONINE METHYL ESTER HYDROCHLORIDE is subject to strict regulations and monitoring by authorities. Its use is limited to specific applications, such as research and pharmaceutical development, to prevent misuse and ensure the safety of the public.
Check Digit Verification of cas no
The CAS Registry Mumber 38969-40-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,9,6 and 9 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 38969-40:
(7*3)+(6*8)+(5*9)+(4*6)+(3*9)+(2*4)+(1*0)=173
173 % 10 = 3
So 38969-40-3 is a valid CAS Registry Number.
InChI:InChI=1/C10H17NO3.ClH/c1-11-6-3-4-7(11)9(8(12)5-6)10(13)14-2;/h6-9,12H,3-5H2,1-2H3;1H/t6-,7+,8-,9+;/m0./s1
38969-40-3Relevant articles and documents
Asymmetric synthesis of the tropane alkaloid (+)-pseudococaine via ring-closing iodoamination
Brock, E. Anne,Davies, Stephen G.,Lee, James A.,Roberts, Paul M.,Thomson, James E.
, p. 4278 - 4281 (2012/09/22)
Ring-closing iodoamination of tert-butyl 2-hydroxy-7-[N-methyl-N-(α- methyl-p-methoxybenzyl)amino]cyclohept-3-ene-1-carboxylates proceeds with concomitant loss of the N-α-methyl-p-methoxybenzyl group to give the corresponding 8-azabicyclo[3.2.1]octane sca
Radioimmunoassay of benzoylecgonine in samples of forensic interest
Robinson,Smith
, p. 157 - 162 (2007/10/02)
A simple and economical radioimmunoassay for benzoylecgonine in blood or urine is described. Haemolysis, decomposition, common anticoagulants and sodium fluoride do not affect the results. A commercially available antiserum is used at a dilution of 1 : 600. The tracer is radioiodinated p-hydroxybenzoylecgonine. It is prepared by reacting p-acetoxy-benzoic anhydride with methyl ecgonine followed by mild hydrolysis and radioiodination by the Iodo-gen method. The product is purified on a disposable silica cartridge and has a specific activity of about 30 TBq mmol-1. Polyethylene glycol is used to separate the bound and free fractions in the assay. The range of the dose-response curve is 0-400 ng ml-1 benzoylecgonine. The assay is largely specific for benzoylecgonine. Cocaine, ecgonine, methylecgonine and cinnamoyl cocaine have slight or negligible cross-reactivities. The inter-assay coefficient of variation is 7.5% and the recovery of benzoylecgonine from 'spiked' blood is 103%. The 'cut-off' is 20 ng ml-1 benzoylecgonine for both blood and urine. Radioimmunoassay and high-performance liquid chromatography results agree well.
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