481-37-8 Usage
Description
ECGONINE HYDROCHLORIDE AMINO ALCOHOL PORTION is a tropane alkaloid derived from the metabolism of cocaine. It consists of a tropane molecule with carboxy and hydroxy substituents at positions 2 and 3, respectively, and has a (1R,2R,3S,5S)-configuration. ECGONINE HYDROCHLORIDE AMINO ALCOHOL POR TION serves as both a metabolite and a precursor to cocaine, playing a significant role in the chemical structure and pharmacological properties of the drug.
Uses
Used in Pharmaceutical Industry:
ECGONINE HYDROCHLORIDE AMINO ALCOHOL PORTION is used as an intermediate compound in the synthesis of various pharmaceutical drugs, particularly those related to the tropane alkaloid family. Its unique chemical structure allows for the development of medications with potential applications in treating various medical conditions.
Used in Research and Development:
In the field of scientific research, ECGONINE HYDROCHLORIDE AMINO ALCOHOL PORTION is utilized as a key component in the study of the chemical properties, synthesis, and pharmacological effects of tropane alkaloids. ECGONINE HYDROCHLORIDE AMINO ALCOHOL POR TION aids researchers in understanding the mechanisms of action, potential side effects, and therapeutic applications of drugs derived from this class of alkaloids.
Used in Drug Metabolism Studies:
ECGONINE HYDROCHLORIDE AMINO ALCOHOL PORTION is employed in the investigation of drug metabolism, specifically in the context of cocaine and its metabolites. By studying the metabolic pathways and the role of this compound, researchers can gain insights into the detoxification processes, potential drug interactions, and the development of addiction and dependence.
Used in Forensic Analysis:
In forensic science, ECGONINE HYDROCHLORIDE AMINO ALCOHOL PORTION can be used as a biomarker for the detection and identification of cocaine use. Its presence in biological samples, such as blood, urine, or hair, can provide evidence of drug consumption, aiding in the investigation of drug-related crimes and the assessment of drug abuse patterns.
Used in Drug Addiction Treatment:
ECGONINE HYDROCHLORIDE AMINO ALCOHOL PORTION may be utilized in the development of novel treatment strategies for drug addiction, particularly cocaine addiction. By understanding the role of this compound in the metabolism and pharmacological effects of cocaine, researchers can potentially design medications or therapies that target the metabolic pathways involved, thereby reducing the addictive potential of the drug and aiding in the recovery process.
Check Digit Verification of cas no
The CAS Registry Mumber 481-37-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,8 and 1 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 481-37:
(5*4)+(4*8)+(3*1)+(2*3)+(1*7)=68
68 % 10 = 8
So 481-37-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H15NO3/c1-10-5-2-3-6(10)8(9(12)13)7(11)4-5/h5-8,11H,2-4H2,1H3,(H,12,13)/t5?,6?,7-,8?/m0/s1
481-37-8Relevant articles and documents
Augmenting the efficacy of anti-cocaine catalytic antibodies through chimeric hapten design and combinatorial vaccination
Wenthur, Cody J.,Cai, Xiaoqing,Ellis, Beverly A.,Janda, Kim D.
, p. 3666 - 3668 (2017)
Given the need for further improvements in anti-cocaine vaccination strategies, a chimeric hapten (GNET) was developed that combines chemically-stable structural features from steady-state haptens with the hydrolytic functionality present in transition-state mimetic haptens. Additionally, as a further investigation into the generation of an improved bifunctional antibody pool, sequential vaccination with steady-state and transition-state mimetic haptens was undertaken. While GNET induced the formation of catalytically-active antibodies, it did not improve overall behavioral efficacy. In contrast, the resulting pool of antibodies from GNE/GNT co-administration demonstrated intermediate efficacy as compared to antibodies developed from either hapten alone. Overall, improved antibody catalytic efficiency appears necessary to achieve the synergistic benefits of combining cocaine hydrolysis with peripheral sequestration.
Computational Design and Crystal Structure of a Highly Efficient Benzoylecgonine Hydrolase
Chen, Xiabin,Deng, Xingyu,Hou, Shurong,Li, Qiang,Tong, Junsen,Wang, Jiye,Wu, Yanan,Xie, Tian,Yang, Kang,Yao, Jianzhuang,Yao, Weixuan,Zhang, Yun
, p. 21959 - 21965 (2021)
Benzoylecgonine (BZE) is the major toxic metabolite of cocaine and is responsible for the long-term cocaine-induced toxicity owing to its long residence time in humans. BZE is also the main contaminant following cocaine consumption. Here, we identified the bacterial cocaine esterase (CocE) as a BZE-metabolizing enzyme (BZEase), which can degrade BZE into biological inactive metabolites (ecgonine and benzoic acid). CocE was redesigned by a reactant-state-based enzyme design theory. An encouraging mutant denoted as BZEase2, presented a >400-fold improved catalytic efficiency against BZE compared with wild-type (WT) CocE. In vivo, a single dose of BZEase2 (1 mg kg?1, IV) could eliminate nearly all BZE within only two minutes, suggesting the enzyme has the potential for cocaine overdose treatment and BZE elimination in the environment by accelerating BZE clearance. The crystal structure of a designed BZEase was also determined.
-
Halmos et al.
, p. 1699 (1957)
-
BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF
-
Paragraph 00435, (2016/10/31)
Bolaamphiphilic compounds are provided according to formula (I); where HG1, HG2 and L1 are as defined herein. Provided bolaamphiphilic compounds and the pharmaceutical compositions thereof are useful for delivering GDNF or NGF into animal or human brain.
This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.