38985-72-7

Basic information

• Product Name: 4-(2-FLUOROPHENYL)-3-THIOSEMICARBAZIDE
• Synonyms: N1-(2-FLUOROPHENYL)HYDRAZINE-1-CARBOTHIOAMIDE;4-(2-fluorophenyl)thiosemicarbazide;4-(2-FLUOROPHENYL)-3-THIOSEMICARBAZIDE;2-FLUOROPHENYLTHIOSEMICARBAZIDE;4-(2-Fluorophenyl)-3-thiosemicarbazide 97%;4-(2-Fluorophenyl)-3-thiosemicarbazide97%;4-(2-FLUOROPHENYL)-3-THIOSEMICARBAZIDE, 98+%;N-(2-fluorophenyl)hydrazinecarbothioamide
• CAS NO: 38985-72-7
• Molecular Formula: C₇H₈FN₃S
• Molecular Weight: 185.22
• EINECS: 254-237-1
• Mol File: 38985-72-7.mol
• Article Data: 12

Chemical Properties

• Melting Point: 159-160°C
• Boiling Point: 278.2 °C at 760 mmHg
• Flash Point: 122 °C
• Appearance: /
• Density: 1.418 g/cm³
• Vapor Pressure: 0.00433mmHg at 25°C
• Refractive Index: 1.696
• BRN: 2212143
• CAS DataBase Reference: 4-(2-FLUOROPHENYL)-3-THIOSEMICARBAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-FLUOROPHENYL)-3-THIOSEMICARBAZIDE(38985-72-7)
• EPA Substance Registry System: 4-(2-FLUOROPHENYL)-3-THIOSEMICARBAZIDE(38985-72-7)

Safety Data

• Hazard Codes: T
• Statements: 36/37/38-25
• Safety Statements: 26-36-45
• RIDADR: 2811
• HazardClass: 6.1
• PackingGroup: II
• Hazardous Substances Data: 38985-72-7(Hazardous Substances Data)

Usage

General Description

4-(2-Fluorophenyl)-3-thiosemicarbazide is a chemical compound with the molecular formula C7H7FN4S. It is a thiosemicarbazide derivative and contains a fluorophenyl substituent. Thiosemicarbazides are known for their biological activities, including antibacterial, antifungal, and antitumor properties. 4-(2-Fluorophenyl)-3-thiosemicarbazide is a potential drug candidate and has been studied for its potential pharmacological activities. Additionally, it has been used as a starting material for the synthesis of various heterocyclic compounds with potential pharmacological applications.

InChI:InChI=1/C7H8FN3S/c8-5-3-1-2-4-6(5)10-7(12)11-9/h1-4H,9H2,(H2,10,11,12)

Upstream product

• 38985-64-7 o-fluorophenyl isothiocyanate 
• 348-54-9 2-Fluoroaniline 
• 75-15-0 carbon disulfide 

Downstream Products

• 73310-96-0 5-(2-fluoro-anilino)-3H-[1,3,4]thiadiazole-2-thione 
• 68371-96-0 (2-fluoro-phenyl)-[1,2,3,4]thiatriazol-5-yl-amine 
• 1221255-85-1 N-(2-fluorophenyl)-2-(quinolin-2-ylmethylene)hydrazinecarbothioamide 
• 502881-14-3 N-(2-fluorophenyl)-2-(5-nitro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-1-hydrazinecarbothioamide 
• 1261295-02-6 C₃₁H₂₂F₈N₆S₄ 
• 1287216-19-6 4-[(10S)-dihydroartemisinin-10-oxy]benzaldehyde N₄-(2-fluorophenyl)thiosemicarbazone 
• 1298017-05-6 C₁₉H₁₅FN₄O₂S 
• 1332336-82-9 N-(2-fluorophenyl)-2-[2-oxo-5-(trifluoromethoxy)-1,2-dihydro-3H-indol-3-ylidene]-1-hydrazinecarbothioamide 
• 1345407-16-0 2-(1H-imidazole-1-yl)-1-(1-biphenyl)ethane-1-one N-(2-fluorophenyl)thiosemicarbazone 
• 1417530-55-2 N-(2-fluorophenyl)-8-methyl-[1,3,4]thiadiazepino[7,6-b]quinolin-2-amine 

Relevant articles and documents

Novel Schiff bases derived from isothiocyanates: synthesis, characterization, and antioxidant activity

A series of novel thiosemicarbazones including Schiff bases were synthesized by treatment of various aryl-substituted aldehydes with thiosemicarbazides in ethanol containing one drop of hydrochloric acid at reflux for 3–5 h. For this, thiosemicarbazides were obtained from hydrazine monohydrate and isothiocyanates in cold dry ethanol at 0 °C for 1 h. FT-IR, 1H NMR, 13C NMR, and LC–MS/MS spectroscopic methods and elemental analysis were used to characterize the identification of the synthesized products. The in vitro antioxidant activity of these compounds was tested by the 1,1-diphenyl-2-picryl hydrazyl (DPPH) free radical trapping method. All of the synthesized compounds showed lower antioxidant activity than the ascorbic acid standard and followed the sequence I > VII > X > VI > IV > IX > XI > II > V > III > VIII.

Synthesis and antibacterial activity of novel Schiff bases of thiosemicarbazone derivatives with adamantane moiety

Increased bacterial resistance to antibiotics is a major threat to human health, and it is particularly important to develop novel antibiotic drugs. Here, we designed a series of Schiff base thiosemicarbazone derivatives containing an adamantane moiety, and carried out the structural characterization of the compounds and in vitro antibacterial activity tests. Compound 7e was as effective as the commonly used antibiotic ampicillin against the Gram-negative bacterium Escherichia coli, and compound 7g had a good inhibitory effect against Gram-positive Bacillus subtilis. These findings provide data for the development of better thiosemicarbazone antibacterial agents.

Synthesis, characterization, and antioxidant activity of some new N 4-arylsubstituted-5-methoxyisatin-β-thiosemicarbazone derivatives

Abstract: Firstly, thiosemicarbazides were prepared by the reaction of hydrazine monohydrate with isothiocyanates in cold dry ethanol at 0?°C for 1?h. After that, new isatin-β-thiosemicarbazones were synthesized by treatment of 5-methoxyisatin with thiose