502881-14-3

Basic information

• Product Name: N-(2-fluorophenyl)-2-(5-nitro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-1-hydrazinecarbothioamide
• Synonyms: N-(2-fluorophenyl)-2-(5-nitro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-1-hydrazinecarbothioamide
• CAS NO: 502881-14-3
• Molecular Weight: 359.341
• Mol File: 502881-14-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(2-fluorophenyl)-2-(5-nitro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-1-hydrazinecarbothioamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-fluorophenyl)-2-(5-nitro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-1-hydrazinecarbothioamide(502881-14-3)
• EPA Substance Registry System: N-(2-fluorophenyl)-2-(5-nitro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-1-hydrazinecarbothioamide(502881-14-3)

Safety Data

• Hazardous Substances Data: 502881-14-3(Hazardous Substances Data)

Upstream product

• 611-09-6 5-nitroisatin 
• 38985-72-7 N-(2-fluorophenyl)hydrazinecarbothioamide 

Relevant articles and documents

5-Nitroisatin-derived thiosemicarbazones: Potential antileishmanial agents

A series of 29 previously reported N4-substituted 5-nitroisatin-3-thiosemicarbazones 2-30 has been screened for leishmanicidal potential. Compounds 2-4, 7, 8, 10-13, 15-19, 21, 23, 24, 26, 28 and 30 exhibited good to excellent antileishmanial activities with IC50 values ranging from 0.44±0.02 to 32.38±0.66μg/mL. Of these, 5, 7, 19 and 28 proved to be the most active antileishmanial agents, displaying activities with IC50 values 1.78±0.35, 0.44±0.02, 1.91±0.04 and 4.28±0.75μg/mL, respectively, which were even better than the standard drug, pentamidine (IC50=5.09±0.04μg/mL). This study presents the first example of exhibition of leishmanicidal potential by isatin-thiosemicarbazones and as such furnishes a solid basis for further research on these compounds to develop more potent antileishmanial agents.